Antioxidant Potential of Plumieride against CCl₄-Induced Peroxidative Damage in Rats

Antioxidants
Dharmendra SinghRadhey Shyam Gupta

Abstract

In search of a new potent as an antioxidant from natural sources, plumieride-an iridoid isolated from the methanol extract of the bark of Plumeria bicolor (family Apocynaceae) was evaluated for its antioxidant potential against CCl₄-induced peroxidative damage in liver of rats. The antioxidant potential was evaluated by using hepatic tissue for SOD (superoxide dismutase), CAT (catalase), GSH (reduced glutathione), GPx (glutathione peroxidase), GR (glutathione reductase) and LPO (lipid peroxidation) alongwith the concomitant blood serum for AST & ALT (aspartate and alanine transaminases), GGT (gamma glutamyl transpeptidase), ALP (alkaline phosphatase), total bilirubin and total protein contents. All the biochemical parameters were significantly (p ≤ 0.001) altered by CCl₄ (0.3 mL/kg body weight/twice a week, intra-peritoneally for 30 days). Simultaneously, oral treatment with plumieride (5, 10 and 20 mg/kg body weight/day for 30 days), restored all the parameters towards a normal level, remarkably. The histological findings of liver sections further corroborated the antioxidant potential of plumieride compared with standard drug-silymarin. In conclusion, plumieride consists of sugar molecules, which have alcoholic groups. Th...Continue Reading

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Citations

Apr 5, 2016·Pharmacognosy Reviews·Fabiana P SoaresMary A M Bandeira
Apr 24, 2021·Journal of Agricultural and Food Chemistry·Francimauro S MoraisMárcio V Ramos

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Methods Mentioned

BETA
column chromatography
Nuclear Magnetic Resonance
NMR

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