PMID: 11605988Oct 19, 2001Paper

Antioxidant properties of acetaminophen and cardioprotection

Basic Research in Cardiology
Gary F Merrill, E Goldberg

Abstract

The acute administration of acetaminophen to isolated, perfused guinea pig hearts appears to have cardioprotective effects against the injury/mechanical dysfunction caused by global, low-flow, myocardial ischemia and reperfusion. In the current study we selected ischemia/reperfusion and administration of sodium pentobarbital as perturbations of the electrical stability of the myocardium. We investigated their ability to induce ventricular arrhythmias and changes in the characteristics of monophasic action potentials in the absence and presence of acetaminophen (0.35 mmol/l). The numbers of ventricular premature beats and ventricular salvos encountered in the presence of pentobarbital were significantly (P < 0.05) reduced by acetaminophen. The combined frequency of these arrhythmias was 0.14+/-0.06/min vs 0.03+/-0.01/min (P < 0.05) in the absence and presence of acetaminophen, respectively. The incidence of ventricular salvos increased steadily in vehicle-treated hearts after administration of pentobarbital. No such trend was seen with acetaminophen. After 10 min of global, low-flow myocardial ischemia, MAP50 and MAP90 (monophasic action potentials at 50 and 90% repolarization, respectively) decreased without acetaminophen (e.g....Continue Reading

Citations

Sep 8, 2010·Rejuvenation Research·Miaozong WuEric R Blough
Apr 10, 2002·American Journal of Therapeutics·W Stewart Hillis
Mar 21, 2009·Annual Review of Biochemistry·Evan T PowersWilliam E Balch
Jan 24, 2007·Physiological Reviews·Pál PacherLucas Liaudet
Apr 9, 2008·Journal of Clinical Biochemistry and Nutrition·Meral Baş Ozsoy, Aysun Pabuçcuoğlu
May 10, 2012·Expert Opinion on Pharmacotherapy·Robert B RaffaJoseph V Pergolizzi
Mar 7, 2009·Microvascular Research·Debjani Tripathy, Paula Grammas
Feb 2, 2008·Biochemical Pharmacology·Howard G ShertzerMary Beth Genter
Sep 30, 2003·Pharmacoepidemiology and Drug Safety·Lynn RosenbergJulie R Palmer
Nov 29, 2005·Neurobiology of Aging·Bruce Ira Gaynes
Jun 21, 2005·Journal of Cardiovascular Pharmacology and Therapeutics·Sharon L Hale, Robert A Kloner
Jul 17, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Gary F MerrillRoseli Golfetti
Sep 21, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Yi Zhun ZhuPhilip K Moore
Feb 27, 2003·Journal of Cardiovascular Pharmacology·Zhi-Dong GeGarrett J Gross
Aug 29, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Stefan SchildknechtMarkus M Bachschmid
Mar 15, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Gary F Merrill
May 30, 2003·Experimental Biology and Medicine·R GolfettiG Merrill
Sep 27, 2007·Experimental Biology and Medicine·Gary F MerrillTyler H Rork
Oct 9, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Norell M HadzimichalisGary F Merrill
Nov 27, 2004·Experimental Biology and Medicine·Tyler H RorkGary F Merrill
May 12, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Bradley G LeshnowerRobert C Gorman
Dec 18, 2002·Experimental Biology and Medicine·Roseli GolfettiGary Merrill
Aug 16, 2008·Experimental Biology and Medicine·Kathryn M Jaques-RobinsonGary F Merrill
Dec 12, 2018·Journal of Cellular Physiology·Homa NomaniAmir Hooshang Mohammadpour

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Related Papers

American Journal of Physiology. Heart and Circulatory Physiology
Norell M HadzimichalisGary F Merrill
Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
Nicholas D Bateman, Euan A Sandilands
© 2021 Meta ULC. All rights reserved