Antioxidant properties of drugs used in Type 2 diabetes management: could they contribute to, confound or conceal effects of antioxidant therapy?

Redox Report : Communications in Free Radical Research
Siu Wai Choi, Cyrus K Ho

Abstract

This is a narrative review, investigating the antioxidant properties of drugs used in the management of diabetes, and discusses whether these antioxidant effects contribute to, confound, or conceal the effects of antioxidant therapy. A systematic search for articles reporting trials, or observational studies on the antioxidant effect of drugs used in the treatment of diabetes in humans or animals was performed using Web of Science, PubMed, and Ovid. Data were extracted, including data on a number of subjects, type of treatment (and duration) received, and primary and secondary outcomes. The primary outcomes were reporting on changes in biomarkers of antioxidants concentrations and secondary outcomes were reporting on changes in biomarkers of oxidative stress. Diabetes Mellitus is a disease characterized by increased oxidative stress. It is often accompanied by a spectrum of other metabolic disturbances, including elevated plasma lipids, elevated uric acid, hypertension, endothelial dysfunction, and central obesity. This review shows evidence that some of the drugs in diabetes management have both in vivo and in vitro antioxidant properties through mechanisms such as scavenging free radicals and upregulating antioxidant gene exp...Continue Reading

References

Dec 16, 1977·European Journal of Clinical Pharmacology·W RiessM Zimmerli
Jan 1, 1993·Journal of Cardiovascular Pharmacology·B HeintzN Bender
Jul 13, 1995·The American Journal of Cardiology·J D SpenceH E Khouri
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·M LevineL R Cantilena
Apr 6, 1999·British Journal of Clinical Pharmacology·A S GrossG M Shenfield
Apr 27, 1999·JAMA : the Journal of the American Medical Association·M LevineY Wang
Apr 29, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·A GazisJ R Cockcroft
Oct 8, 1999·Journal of the American College of Nutrition·J W AndersonP R Oeltgen
Sep 27, 2000·Journal of Diabetes and Its Complications·R C O'BrienJ Mercuri
Apr 24, 2001·Diabetes Care·C S ShinH K Lee
May 31, 2001·The American Journal of Clinical Nutrition·M K Horwitt
Aug 18, 2001·The British Journal of Nutrition·P Evans, B Halliwell
Sep 22, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·W A OranjeB H Wolffenbuttel
Nov 21, 2001·The Journal of Clinical Investigation·M TakemotoJ K Liao
Feb 7, 2002·JAMA : the Journal of the American Medical Association·Antti JulaTapani Rönnemaa
Feb 9, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Sven WassmannGeorg Nickenig
Feb 9, 2002·Cell Biochemistry and Function·Mine Erden-InalGüngör Kanbak
May 29, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ilham SeghrouchniAndré Revol
Jun 22, 2002·Drugs·Jane K McGavinKaren L Goa
Sep 5, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·D FavaG De Mattia
Sep 21, 2002·Current Medical Research and Opinion·Moses Elisaf
Nov 13, 2002·European Journal of Clinical Nutrition·J M HodgsonK D Croft
Dec 17, 2002·Diabetes Research and Clinical Practice·Tsvetalina TankovaGeorgi Kirilov
Apr 4, 2003·JAMA : the Journal of the American Medical Association·Mehdi H ShishehborStanley L Hazen
Jul 26, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Joshua A BeckmanMark A Creager
Oct 11, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Zsolt BagiGabor Kaley
May 22, 2004·Journal of Atherosclerosis and Thrombosis·Jing-Zhi GuanToshihiro Suda
Jun 9, 2004·Hypertension·Kwang Kon KohEak Kyun Shin
Jun 11, 2004·European Journal of Pharmacology·Jan SkrhaRichard Ceska
Jul 9, 2004·Coronary Artery Disease·Jean DavignonR Preston Mason
Sep 3, 2004·Diabetes/metabolism Research and Reviews·Shuhei NakanishiNobuoki Kohno
Sep 30, 2004·Free Radical Biology & Medicine·Edimar C PereiraDulcineia S P Abdalla

❮ Previous
Next ❯

Citations

Nov 2, 2018·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Dina MaalikiAli H Eid
Mar 10, 2020·Oxidative Medicine and Cellular Longevity·Jeremiah Oshiomame Unuofin, Sogolo Lucky Lebelo
Jun 9, 2020·Oxidative Medicine and Cellular Longevity·Rossella D'OriaFrancesco Giorgino
Sep 30, 2019·Free Radical Biology & Medicine·Emil List LarsenHenrik Enghusen Poulsen
Oct 21, 2020·Mechanisms of Ageing and Development·Fabianne Martins RibeiroCelso Vataru Nakamura
Oct 9, 2020·Yeungnam University Journal of Medicine·Soyoung Park, So-Young Park

❮ Previous
Next ❯

Methods Mentioned

BETA
MDA
electrophoresis
amputation
hormone replacement therapy

Related Concepts

Related Feeds

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Related Papers

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
M VucićS J Ashcroft
Free Radical Biology & Medicine
P H Proctor
Przegla̧d lekarski
Ewa Kostrzewa-Zabłocka
Archives des sciences physiologiques
A LOUBATIERESF DE LACLOS
Verhandlungen der Deutschen Gesellschaft für Innere Medizin
W Ewald
© 2022 Meta ULC. All rights reserved