Antioxidant Properties of Fullerene Derivatives Depend on Their Chemical Structure: A Study of Two Fullerene Derivatives on HELFs

Oxidative Medicine and Cellular Longevity
V A SergeevaS V Kostyuk

Abstract

Oxidative stress is a major issue in a wide number of pathologies (neurodegenerative, cardiovascular, immune diseases, and cancer). Because of this, the search for new antioxidants is an important issue. One of the potential antioxidants that has been enthusiastically discussed in the past twenty years is fullerene and its derivatives. Although in aqueous solutions fullerene derivatives have shown to be antioxidants, their properties in this regard within the cells are controversially discussed. We have studied two different water-soluble fullerene C60 and C70 derivatives on human embryonic lung fibroblasts at a wide range of concentrations. Both of them cause a decrease in cellular ROS at short times of incubation (1 hour). Their prolonged action, however, is fundamentally different: derivative GI-761 causes secondary oxidative stress whereas derivative VI-419-P3K keeps ROS levels under control values. To gain a better understanding of this effect, we assessed factors that could play a role in the response of cells to fullerene derivatives. Increased ROS production occurred due to NOX4 upregulation by GI-761. Derivative VI-419-P3K activated the transcription of antioxidant master regulator NRF2 and caused its translocation to ...Continue Reading

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Citations

May 6, 2020·International Journal of Nanomedicine·Hung-Jin HuangShan-Hui Hsu
May 13, 2021·Journal of Wound Care·Ruan Na, Tian Wei
Jun 11, 2021·Frontiers in Chemistry·Gurpal SinghRavi Pratap Barnwal
Jul 3, 2021·International Journal of Molecular Sciences·Ekaterina S KovelNadezhda S Kudryasheva

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Methods Mentioned

BETA
confocal microscopy
fluorescence assay
electrophoresis
flow cytometry
PCR
fluorescence microscopy
flow

Software Mentioned

StatPlus2007

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