PMID: 11933137Apr 5, 2002Paper

Antioxidant properties of silybin glycosides

Phytotherapy Research : PTR
Pavel KosinaDaniela Walterová

Abstract

New soluble derivatives of the hepatoprotective flavonolignan silybin (1), namely silybin galactoside (2), glucoside (3), lactoside (4) and maltoside (5) were investigated for their radical scavenging and antilipoperoxidation properties. According to cyclic voltammetry the results show that glycosides are weaker electron donors than silybin, although it was of interest that they were found to be more potent scavengers of the 1,1-diphenyl-2-picrylhydrazyl and the 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)-derived radicals. The glycosides (2)-(5) were more efficient than silybin in preventing tert-butylhydroperoxide-induced lipoperoxidation of rat liver mitochondrial membranes. Furthermore, glycosides (2)-(5) were significantly more cytoprotective than silybin in tert-butylhydroperoxide-damaged rat erythrocytes and primary hepatocyte cultures. Glycosylation of silybin substantially reduced its toxic effects in primary cultured hepatocytes observed during prolonged incubation. These results suggest that silybin glycosides are suitable soluble derivatives of silybin for experimental studies and may have therapeutic potential.

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Citations

Jun 3, 2011·World Journal of Gastroenterology : WJG·Carmela Loguercio, Davide Festi
Sep 6, 2013·Journal of Industrial Microbiology & Biotechnology·Nguyen Huy Thuan, Jae Kyung Sohng
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Oct 25, 2006·Journal of Enzyme Inhibition and Medicinal Chemistry·Leixiang YangYu Zhao
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Jun 25, 2005·Journal of Biochemical and Molecular Toxicology·Pavel KosinaZdenek Dvorák
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