Antioxidant Proteins' Identification Based on Support Vector Machine.

Combinatorial Chemistry & High Throughput Screening
Yuanke XuGuosheng Han

Abstract

Evidence have increasingly indicated that for human disease, cell metabolism are deeply associated with proteins. Structural mutations and dysregulations of these proteins contribute to the development of the complex disease. Free radicals are unstable molecules that seek for electrons from the surrounding atoms for stability. Once a free radical binds to an atom in the body, a chain reaction occurs, which causes damage to cells and DNA. An antioxidant protein is a substance that protects cells from free radical damage. Accurate identification of antioxidant proteins is important for understanding their role in delaying aging and preventing and treating related diseases. Therefore, computational methods to identify antioxidant proteins have become an effective prior-pinpointing approach to experimental verification. In this study, support vector machines was used to identify antioxidant proteins, using amino acid compositions and 9-gap dipeptide compositions as feature extraction, and feature reduction by Principal Component Analysis. The prediction accuracy Acc of this experiment reached 98.38%, the recall rate Sn of the positive sample was found to be 99.27%, the recall rate Sp of the negative sample reached 97.54%, and the M...Continue Reading

References

Aug 1, 1998·Mutation Research·R P WoychikE D Avrer
Jun 24, 2000·Nature·A Pandey, M Mann
Jul 13, 2000·Free Radical Biology & Medicine·P MecocciU Senin
Feb 19, 2002·The International Journal of Biochemistry & Cell Biology·Zhi-Ping Feng, Chun-Ting Zhang
Dec 21, 2010·Journal of Theoretical Biology·Kuo-Chen Chou
Jul 1, 2010·Pharmacognosy Reviews·V LoboN Chandra
Oct 13, 2012·Bioinformatics·Limin FuWeizhong Li
Nov 3, 2012·Journal of Theoretical Biology·Enrique Fernández-BlancoJulian Dorado
Jan 11, 2013·Nucleic Acids Research·Wei ChenKuo-Chen Chou
Mar 26, 2013·BMC Bioinformatics·Rok Blagus, Lara Lusa
Sep 26, 2013·Computational and Mathematical Methods in Medicine·Peng-Mian FengWei Chen
Jan 24, 2015·Science·Mathias UhlénFredrik Pontén
Sep 9, 2015·Interdisciplinary Sciences, Computational Life Sciences·Pengmian FengHao Lin
Jun 20, 2018·International Journal of Molecular Sciences·Lei XuChangrui Liao
Oct 18, 2019·Frontiers in Bioengineering and Biotechnology·Chaolu MengQuan Zou

❮ Previous
Next ❯

Citations

May 27, 2020·Combinatorial Chemistry & High Throughput Screening·Guohua Huang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.