Antioxidant response analysis in the brain after pilocarpine treatments

Brain Research Bulletin
S TejadaS Esteban

Abstract

Cholinergic and gabaergic systems play an important role generating electroencephalographic activity and regulating vigilance states. Pilocarpine is a cholinergic agonist commonly used to induce seizures and an epilepticus-like state in rodents. A relationship between status epilepticus and reactive oxygen species has been also suggested which could result in seizure-induced neurodegeneration. The aim of this study was to evaluate the existence of oxidative damage as well as the antioxidant enzyme response in cortex and hippocampus after the administration of an intraperitoneal (350 mg/kg) and an intracerebroventricular (360 microg, 1 microl) pilocarpine injection in rats. The GABA agonist muscimol (1 mg/kg, i.p.), with described neuroprotective properties, was used as a negative control. Only systemic pilocarpine induced oxidative damage. Malondialdehyde levels, as a marker of lipid peroxidation (LP), increased in both regions (55-56%). Catalase (52-80%) and superoxide dismutase (53-60%) activities also rose in both regions but glutathione peroxidase activity only increased in cortex (45%). Glutathione reductase and caspase-3 activity did not change. In conclusion, systemic pilocarpine produced oxidative brain damage, whereas ...Continue Reading

References

Aug 1, 1992·Molecular and Chemical Neuropathology·A Y SunF Oldfield
May 15, 1973·FEBS Letters·L FloheH H Schock
May 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·J M McCordI Fridovich
Jan 1, 1984·Methods in Enzymology·L Flohé, W A Günzler
Jul 1, 1993·British Medical Bulletin·K H Cheeseman, T F Slater
Nov 1, 1995·Pharmacology, Biochemistry, and Behavior·L L LoboS Tufik
Jul 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M LancelJ Faulhaber
Mar 1, 1997·Journal of Neurophysiology·M LancelR A Deisz
May 14, 1998·Neuroscience and Biobehavioral Reviews·H C Dringenberg, C H Vanderwolf
May 14, 1999·Journal of the Autonomic Nervous System·R CecanhoL A De Luca
May 21, 1999·The Journal of Biological Chemistry·H SakahiraS Nagata
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y RongM Baudry
Mar 22, 2002·Journal of Neurochemistry·Renu SahRochelle D Schwartz-Bloom
Apr 2, 2002·Biological Psychiatry·Michael L PerlisDonna E Giles
Jul 10, 2002·Archives of Oral Biology·Thiago dos Santos MoreiraJosé Vanderlei Menani
Aug 2, 2002·Epilepsy Research·J P LeiteE A Cavalheiro
Sep 21, 2002·Brain Research Bulletin·A RenziJ V Menani
Jan 1, 2003·Brain Research Bulletin·Ana Carolina Thomaz TakakuraJosé Vanderlei Menani
Nov 19, 2003·JPEN. Journal of Parenteral and Enteral Nutrition·Valentina K TodorovaV Suzanne Klimberg
Dec 11, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·B L C FerreiraC Timo-Iaria
Jan 30, 2004·Neuroscience Letters·Maricilia S CostaMaria da Graça Naffah-Mazzacoratti
Jul 21, 2004·Brain Research·Laurence M KatzKyunam Park
Jul 29, 2004·Cancer Causes & Control : CCC·Paloma CejasManuel González-Barón
Nov 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ming-Chu XiMichael H Chase

❮ Previous
Next ❯

Citations

Jun 26, 2013·Annals of Transplantation : Quarterly of the Polish Transplantation Society·Tomohide HoriJustin H Nguyen
Oct 5, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ítala Mônica dos Santos SalesRivelilson Mendes de Freitas
Jun 27, 2013·Cellular and Molecular Neurobiology·Carlos Clayton Torres AguiarSilvânia Maria Mendes Vasconcelos
Dec 2, 2008·Expert Opinion on Pharmacotherapy·P Uma DeviDivya Vohora
Dec 15, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jaroslava FolbergrováJosef Houštěk
Sep 27, 2012·The Journal of Surgical Research·Tomohide HoriJustin H Nguyen
Oct 6, 2009·Brain Research Bulletin·Rizângela Lyne Mendes de FreitasRivelilson Mendes de Freitas
Sep 1, 2009·Neurochemistry International·Gardenia Carmen Gadelha MilitãoRivelilson Mendes de Freitas
May 16, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Lindsay B GardnerJustin H Nguyen
Nov 8, 2011·Epilepsy & Behavior : E&B·Joaquim Soares da Costa JúniorRivelilson Mendes de Freitas
Jul 13, 2011·European Journal of Pharmacology·Pauline Sousa dos SantosRivelilson Mendes de Freitas
Oct 5, 2016·Experimental and Therapeutic Medicine·Liliana Carmona-AparicioNoemí Cárdenas-Rodríguez
Feb 2, 2019·Molecular Biology Reports·Niraj Kumar SrivastavaDeepak Sharma
Oct 22, 2019·Frontiers in Neurology·Carlos Roberto Porto DechandtLuciane Carla Alberici
Dec 18, 2013·Physiological Research·J Folbergrová
Sep 21, 2018·Brain Research Bulletin·Rosângela Figueiredo Mendes-da-SilvaRubem Carlos Araújo Guedes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.