Antioxidant supplementation in pregnant women with low antioxidant status

The Journal of Obstetrics and Gynaecology Research
Noroyono WibowoIka Fitriana

Abstract

The aim of this study was to investigate the benefit of antioxidant supplementation in a cohort of women with low antioxidant status and determine the changes in cell-free mRNA. This study was a randomized, placebo-controlled trial of 8-12 weeks' pregnant women who had low antioxidant status treated with either antioxidants or control diets daily until 2 weeks' postpartum. The primary end-point was the risk of pre-eclampsia and the secondary end-point was the changes of angiogenic and anti-oxidant mRNA markers related to the outcome (ClinicalTrial.gov, number NCT01232205). There were 110 women enrolled in the study, randomly assigned to the supplementation (n = 52) and control group (n = 58). The overall rate of pre-eclampsia was 8.7% (nine subjects). There were significant differences (P = 0.034) between the supplementation and control group in the incidence of pre-eclampsia (2.0% [one case] and 14.5% [eight cases], respectively) and mRNA level of superoxide-dismutase, heme oxygenase-1, vascular endothelial growth factor receptor-1, endoglin and placental growth factor after supplementation. Supplementation of women with low antioxidant status with micronutrients containing antioxidants during early gestation might reduce the ...Continue Reading

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Citations

Apr 29, 2015·Nutrition Research·Arpita BasuTimothy J Lyons
Jul 11, 2014·Frontiers in Pharmacology·Emilio A HerreraAnibal J Llanos
Apr 28, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Hamid Reza NejabatiMohammad Nouri
Mar 16, 2019·The Cochrane Database of Systematic Reviews·Emily C KeatsZulfiqar A Bhutta
Oct 17, 2018·Mini Reviews in Medicinal Chemistry·Seyithan TaysiMustafa Demir
Apr 14, 2017·The Cochrane Database of Systematic Reviews·Batool A Haider, Zulfiqar A Bhutta
May 7, 2016·The Cochrane Database of Systematic Reviews·Olukunmi O BalogunRintaro Mori
Sep 8, 2015·The Cochrane Database of Systematic Reviews·Alice RumboldCaroline A Crowther
Nov 30, 2019·Oxidative Medicine and Cellular Longevity·Marilene Brandão TenórioMarília Oliveira Fonseca Goulart
Feb 26, 2020·Diabetology & Metabolic Syndrome·Hebah Alawi Kutbi, Sahar Ali Hammouda
Nov 19, 2021·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Yun Liu, Qingfang Meng

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