Antioxidant supplementation, redox deficiencies and exercise performance: A falsification design.

Free Radical Biology & Medicine
Nikos V MargaritelisMichalis G Nikolaidis

Abstract

The aim of the present study was to validate the idea of personalized redox supplementation by subjecting individuals to targeted and non-targeted antioxidant supplementation schemes. Seventy-three volunteers were screened for plasma vitamin C and erythrocyte glutathione levels. Three groups were formed: i) the "low vitamin C″ group (12 individuals with the lowest vitamin C levels; Low VitC), ii) the "low glutathione" group (12 individuals with the lowest glutathione levels; Low GSH) and iii) a control group (12 individuals with moderate vitamin C and glutathione levels). The three groups received 1 g of vitamin C or 1.2 g of NAC daily for 30 days in a crossover design with a wash-out period of 30 days. Both antioxidant treatments reduced the increased resting systemic oxidative stress levels, assessed via urine F2-isoprostanes, in the Low VitC and Low GSH groups (P < .05). A significant group × time interaction (P < .05) was found for VO2max and isometric peak torque after both treatments, with the Low VitC and Low GSH groups exhibiting improved performance only after the targeted treatment (vitamin C and NAC, respectively). A significant group × time interaction (P < .05) was found for fatigue index after NAC treatment, but n...Continue Reading

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Sep 7, 2016·Free Radical Research·Nikos V MargaritelisMichalis G Nikolaidis
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Sep 27, 2018·Advances in Nutrition·Nikos V MargaritelisMichalis G Nikolaidis
Mar 21, 2020·Redox Biology·N V MargaritelisM G Nikolaidis

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Citations

Sep 1, 2020·Free Radical Biology & Medicine·Ethan L Ostrom, Tinna Traustadóttir
Oct 16, 2020·Free Radical Biology & Medicine·Barry Halliwell
Aug 23, 2021·Journal of the International Society of Sports Nutrition·S C BroomeT L Merry
Sep 4, 2021·IUBMB Life·Nikos V MargaritelisMichalis G Nikolaidis
Aug 24, 2021·The British Journal of Nutrition·Alex GriffithsOliver Michael Shannon

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