Antioxidant supplements and endurance exercise: Current evidence and mechanistic insights.

Redox Biology
Shaun A MasonGlenn D Wadley

Abstract

Antioxidant supplements are commonly consumed by endurance athletes to minimize exercise-induced oxidative stress, with the intention of enhancing recovery and improving performance. There are numerous commercially available nutritional supplements that are targeted to athletes and health enthusiasts that allegedly possess antioxidant properties. However, most of these compounds are poorly investigated with respect to their in vivo redox activity and efficacy in humans. Therefore, this review will firstly provide a background to endurance exercise-related redox signalling and the subsequent adaptations in skeletal muscle and vascular function. The review will then discuss commonly available compounds with purported antioxidant effects for use by athletes. N-acetyl cysteine may be of benefit over the days prior to an endurance event; while chronic intake of combined 1000 mg vitamin C + vitamin E is not recommended during periods of heavy training associated with adaptations in skeletal muscle. Melatonin, vitamin E and α-lipoic acid appear effective at decreasing markers of exercise-induced oxidative stress. However, evidence on their effects on endurance performance are either lacking or not supportive. Catechins, anthocyanins, ...Continue Reading

Citations

Sep 15, 2020·Journal of the American College of Nutrition·Jeffrey A RothschildDaniel J Plews
Apr 15, 2020·International Journal of Molecular Sciences·Francesca OppedisanoVincenzo Mollace
Dec 30, 2020·Nutrients·Aneta Otocka-Kmiecik, Aleksandra Król
Mar 5, 2021·Advanced Healthcare Materials·Takuto ToriumiYukio Nagasaki
Mar 31, 2021·Journal of the International Society of Sports Nutrition·Jason P Brandenburg, Luisa V Giles
May 12, 2021·Free Radical Biology & Medicine·Rosa Paola RadiceGiovanna Bermano
Jul 20, 2020·Free Radical Biology & Medicine·Nikos V MargaritelisMichalis G Nikolaidis
Jun 3, 2021·Antioxidants·Leandro Kansuke OharomariHideaki Soya
Jun 15, 2021·Journal of Agricultural and Food Chemistry·Xuan MaHongbo Hu
Jun 25, 2021·Journal of Ethnopharmacology·Xiaohan WeiXiaomei Tan
Aug 23, 2021·Journal of the International Society of Sports Nutrition·S C BroomeT L Merry
Sep 3, 2021·The Journal of Physiological Sciences : JPS·Joanna KrukEwa Duchnik

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Methods Mentioned

BETA
acetylation
electron paramagnetic resonance
transgenic

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