Antioxidant therapy in male infertility

The Urologic Clinics of North America
Sutchin R Patel, Mark Sigman

Abstract

Although reports have suggested the benefit of antioxidant treatment of infertile men, many studies also show no effect. Most studies in the literature are not randomized, placebo controlled, or double blinded in design, which makes it difficult to differentiate regression toward the mean from true positive treatment effects. The small patient sample sizes and varying male populations also add to the difficulty in comparing studies. Pregnancy, the most relevant outcome parameter, is rarely reported. Ideally, patients would be selected based on oxidative stress levels, and improvement in these levels would be correlated to improvement in pregnancy rates. Until those studies are performed, the use of antioxidants for the treatment of male infertility remains empiric.

References

Dec 1, 1990·Biochemical Society Transactions·P Di MascioH Sies
Jan 1, 1990·Methods in Enzymology·B Halliwell, J M Gutteridge
Jul 1, 1989·Biology of Reproduction·R J AitkenS Fishel
Nov 1, 1989·Archives of Biochemistry and Biophysics·P Di MascioH Sies
Oct 1, 1987·Annals of Internal Medicine·C E CrossD Harman
Jan 1, 1997·Molecular Aspects of Medicine·A Lewin, H Lavon
Apr 1, 1997·International Journal of Andrology·J F Griveau, D Le Lannou
Jan 1, 1996·Reviews of Reproduction·D S Irvine
Aug 4, 1998·Human Reproduction·A LenziM Picardo
Sep 19, 2000·Prostaglandins, Leukotrienes, and Essential Fatty Acids·F H ComhaireC E Depuydt
Feb 6, 2003·Fertility and Sterility·Robert KünzleNick A Bersinger
May 2, 2003·Human Reproduction·Michele De RosaGaetano Lombardi
Jun 13, 2003·Fertility and Sterility·Nicolai WroblewskiRalf Henkel
Nov 18, 2003·Reproductive Biology and Endocrinology : RB&E·Ralf R Henkel, Wolf-Bernhard Schill
May 20, 2004·Reproductive Biomedicine Online·A Agarwal, Tamer M Said
Jun 1, 2004·Reproductive Biomedicine Online·Ashok AgarwalTamer M Said

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Citations

Jan 6, 2011·Der Urologe. Ausg. A·M TrottmannA J Becker
Mar 7, 2012·Archives of Gynecology and Obstetrics·Sandro C EstevesAshok Agarwal
Apr 18, 2015·Journal of Obstetrics and Gynaecology of India·Ashok AgarwalSandro C Esteves
May 17, 2017·Nature Reviews. Urology·Shilpa BishtRima Dada
Mar 6, 2017·Chinese Journal of Natural Medicines·Hnin Ei ThuAhmad Nazrun Shuid
Dec 17, 2014·The Cochrane Database of Systematic Reviews·Marian G ShowellRoger J Hart
Mar 14, 2019·The Cochrane Database of Systematic Reviews·Roos M SmitsMarian G Showell
Jun 21, 2011·Asian Journal of Andrology·Francesco LombardoAndrea Lenzi
Mar 2, 2021·Clinical and Experimental Reproductive Medicine·Masoomeh MohammadzadehAli Reza Talebi

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