Antioxidant therapy reverses impaired graft healing in hypercholesterolemic rabbits.

Journal of Vascular Surgery
Michael A RosenbaumLinda M Graham

Abstract

Limited endothelial cell (EC) coverage and anastomotic intimal hyperplasia contribute to thrombosis and failure of prosthetic grafts. Lipid accumulation and lipid oxidation are associated with decreased EC migration and intimal hyperplasia. The goal of this study was to assess the ability of antioxidants to improve graft healing in hypercholesterolemic animals. Rabbits were placed in one of four groups: chow plus N-acetylcysteine (NAC), chow plus probucol, chow with 1% cholesterol plus NAC, or chow with 1% cholesterol plus probucol. After 2 weeks, expanded polytetrafluoroethylene grafts (12 cm long x 4-mm internal diameter) were implanted in the abdominal aorta. Grafts were removed after 6 weeks and analyzed for cholesterol content, EC coverage, anastomotic intimal thickness, and the cellular composition of the neointima. Plasma samples were obtained to assess systemic oxidative stress. The data were compared with previously reported data from animals fed diets of chow and chow with 1% cholesterol. Prosthetic grafts from rabbits fed chow with 1% cholesterol had significantly greater anastomotic intimal thickening and lower EC coverage than grafts from rabbits fed a regular chow diet. In hypercholesterolemic rabbits, antioxidant...Continue Reading

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Citations

Dec 3, 2014·Journal of Vascular Surgery·Valerio TolvaFrancesco Cilurzo
Mar 27, 2012·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Mowei SongYe Tian
Oct 13, 2016·Oxidative Medicine and Cellular Longevity·Yuanyuan CuiKeji Chen
Feb 25, 2021·American Journal of Physiology. Cell Physiology·Pinaki ChaudhuriMichael A Rosenbaum
Mar 11, 2021·American Journal of Physiology. Cell Physiology·Pinaki ChaudhuriMichael A Rosenbaum

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