Abstract
Limited endothelial cell (EC) coverage and anastomotic intimal hyperplasia contribute to thrombosis and failure of prosthetic grafts. Lipid accumulation and lipid oxidation are associated with decreased EC migration and intimal hyperplasia. The goal of this study was to assess the ability of antioxidants to improve graft healing in hypercholesterolemic animals. Rabbits were placed in one of four groups: chow plus N-acetylcysteine (NAC), chow plus probucol, chow with 1% cholesterol plus NAC, or chow with 1% cholesterol plus probucol. After 2 weeks, expanded polytetrafluoroethylene grafts (12 cm long x 4-mm internal diameter) were implanted in the abdominal aorta. Grafts were removed after 6 weeks and analyzed for cholesterol content, EC coverage, anastomotic intimal thickness, and the cellular composition of the neointima. Plasma samples were obtained to assess systemic oxidative stress. The data were compared with previously reported data from animals fed diets of chow and chow with 1% cholesterol. Prosthetic grafts from rabbits fed chow with 1% cholesterol had significantly greater anastomotic intimal thickening and lower EC coverage than grafts from rabbits fed a regular chow diet. In hypercholesterolemic rabbits, antioxidant...Continue Reading
References
Apr 1, 1976·Biochemical Medicine·K Yagi
Apr 1, 1992·Molecular and Cellular Biochemistry·S Chatterjee
Nov 1, 1990·Lipids·E H GohS M Colles
Jan 1, 1989·Free Radical Biology & Medicine·O I AruomaJ Butler
Nov 22, 1984·The New England Journal of Medicine·L CampeauA Sniderman
Mar 1, 1994·Journal of Vascular Surgery·D S BaumannG Schonfeld
Jun 1, 1994·Circulation Research·G MurugesanP L Fox
Feb 1, 1993·The Journal of Cell Biology·G MurugesanP L Fox
Apr 1, 1993·Archives of Surgery·A F AbuRahmaJ P Boland
Jan 7, 1998·The New England Journal of Medicine·C R Sirtori, G Franceschini
Jan 22, 2000·Journal of Vascular Surgery·J A van AalstL M Graham
Sep 29, 2000·The American Journal of Cardiology·H DaidaH Yamaguchi
May 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S CuzzocreaA P Caputi
Jul 19, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Afaf AbsoodLinda M Graham
Apr 19, 2003·Circulation·Antony K LauRoland Stocker
Jun 6, 2003·Kidney International·Véronique Witko-SarsatBéatrice Descamps-Latscha
May 15, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Afaf AbsoodLinda M Graham
Sep 24, 2004·Physiological Reviews·Roland Stocker, John F Keaney
Dec 29, 2004·Journal of Vascular Surgery·John A van AalstLinda M Graham
Mar 15, 2006·Atherosclerosis·David TanousRoland Stocker
Apr 12, 2006·The Journal of Experimental Medicine·Ben J WuRoland Stocker
May 27, 2006·Current Pharmaceutical Biotechnology·En-Hui YaoNoboru Fukuda
Mar 27, 2007·American Journal of Preventive Medicine·Matthew A AllisonMichael H Criqui
Dec 22, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Nele GeudensDirk E M Van Raemdonck
Citations
Jan 31, 2012·Cardiovascular Research·Qiang SunAtsunori Nakao
Nov 13, 2013·International Journal of Molecular Sciences·Leng NiChangwei Liu
Dec 3, 2014·Journal of Vascular Surgery·Valerio TolvaFrancesco Cilurzo
Mar 27, 2012·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Mowei SongYe Tian
Jul 1, 2015·Atherosclerosis·Michael A RosenbaumLinda M Graham
Oct 13, 2016·Oxidative Medicine and Cellular Longevity·Yuanyuan CuiKeji Chen
Apr 22, 2016·Biomedical Materials·Karamveer BirthareChris A Bashur
Feb 25, 2021·American Journal of Physiology. Cell Physiology·Pinaki ChaudhuriMichael A Rosenbaum
Mar 11, 2021·American Journal of Physiology. Cell Physiology·Pinaki ChaudhuriMichael A Rosenbaum