Antioxidant treatment with alpha-tocopherol improves erectile function in hypertensive rats

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Masayuki UshiyamaShigehiro Katayama

Abstract

There is no known treatment for erectile dysfunction (ED) in hypertensive patients. We tested whether or not antioxidative therapy improves ED in the setting of hypertension. Spontaneously hypertensive rats (SHRs) were treated with a control chow or an alpha-tocopherol-enriched chow (12 or 24 mg/100 g chow) for 8 weeks. The isometric tension of corpus cavernosum strips from these SHRs was recorded. nNOS and HO-2 gene expression and NOx, cGMP, thiobarbituric acid-reacting substance (TBARS), and superoxide dismutase (SOD) activity levels were determined in serum and tissue. Relaxation in response to electrical field stimulation (EFS) in the corpus cavernosum increased after the administration of alpha-tocopherol at a dose of 24 mg/100 g chow. This effect was inhibited by a nitric oxide synthase (NOS) inhibitor and by a heme oxygenase (HO) inhibitor, nNOS and HO-2 gene expression and NOx concentrations in the corpus cavernosum were similar between 24 mg alpha-tocopherol-fed SHRs and controls. Tissue cGMP levels were greater in alpha-tocopherol-fed SHRs than in controls. Treatment with 24 mg alpha-tocopherol decreased TBARS levels and increased SOD activity in the serum and corpus cavernosum. Relaxation in response to acetylcholine...Continue Reading

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May 7, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masayuki UshiyamaShigehiro Katayama

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Citations

Mar 17, 2010·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·M GalianoR Virag
Sep 15, 2012·The Journal of Sexual Medicine·Selim CellekChing-Shwun Lin
Jul 5, 2012·The Journal of Sexual Medicine·Kelly DecaluwéJohan Van de Voorde
Jun 16, 2009·The Journal of Sexual Medicine·Carla Costa, Ronald Virag
Jun 15, 2011·Journal of Bioscience and Bioengineering·Wei ZhangTingyi Bao
Mar 26, 2014·British Journal of Pharmacology·G Yetik-AnacakN Murat
Jan 14, 2012·Current Opinion in Nephrology and Hypertension·Kenia Pedrosa NunesR Clinton Webb

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