Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration

The Cochrane Database of Systematic Reviews
J Evans

Abstract

It has been proposed that antioxidants may prevent cellular damage in the retina by reacting with free radicals that are produced in the process of light absorption. The objective of this review was to assess the effects of antioxidant vitamin or mineral supplementation, or both, on the progression of age-related macular degeneration (AMD). We searched the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library (2005, Issue 4); MEDLINE (1966 to January 2006); SIGLE (1980 to March 2005); EMBASE (1980 to January 2005); NRR (2005, Issue 4); AMED (1985 to January 2006); and PubMed (24 January 2006 covering last 60 days), reference lists of identified reports and the Science Citation Index. We contacted investigators and experts in the field for details of unpublished studies. We included randomised trials comparing antioxidant vitamin or mineral supplemention (alone or in combination) to a control intervention in people with AMD. The author extracted data and assessed trial quality. Where appropriate, data were pooled using a random-effects model unless three or fewer trials were available in which case a fixed-effects model was used. Eight trials were included in this review. The majority of people were ra...Continue Reading

Citations

Jun 12, 2012·European Journal of Nutrition·Heiner BoeingBernhard Watzl
Sep 24, 2010·International Ophthalmology·Ian Yat Hin WongClement Wai Nang Chan
Feb 7, 2012·Antioxidants & Redox Signaling·Anne M FitzpatrickLou Ann S Brown
Mar 11, 2010·Current Opinion in Ophthalmology·Nupura KrishnadevEmily Y Chew
Mar 16, 2012·The Cochrane Database of Systematic Reviews·Alex PollockUma Shahani
Jul 19, 2008·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Peter van Wijngaarden, Salmaan H Qureshi
May 17, 2007·British Journal of Community Nursing·Anna Denny
Feb 27, 2013·The Cochrane Database of Systematic Reviews·Arthur GeltzerSatyanarayana S Vedula
Feb 17, 2017·The Cochrane Database of Systematic Reviews·Heather CasparisNeil M Bressler
Jul 19, 2020·International Journal of Molecular Sciences·Janusz BlasiakKai Kaarniranta
Oct 10, 2008·The Cochrane Database of Systematic Reviews·Chiara M EandiGianni Virgili
Aug 2, 2017·The Cochrane Database of Systematic Reviews·Jennifer R Evans, John G Lawrenson
Apr 17, 2009·The Cochrane Database of Systematic Reviews·Fabrizio GiansantiGianni Virgili
Mar 14, 2014·Deutsches Ärzteblatt International·Bernhard H F WeberFrank G Holz
Oct 24, 2007·American Journal of Ophthalmology·Barbara E K Klein, Ronald Klein

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