Antioxidant vitamin supplements and markers of bone turnover in a community sample of nonsmoking women

Journal of Women's Health
Julie A PascoMark A Kotowicz

Abstract

Whereas several epidemiological studies suggest that low dietary intake of vitamins C and E is linked to increased hip fracture in smokers and antioxidants (dietary and endogenous) are reduced in elderly osteoporotic women, none has demonstrated an effect of supplemental antioxidants on bone turnover. In an observational study of 533 randomly selected women, we investigated the associations among the use of antioxidant supplements, vitamins C and E, serum levels of biochemical markers of bone turnover (C-telopeptide [CTx] and bone-specific alkaline phosphatase [BSAP]), and whole body bone mineral density (BMD). Twenty-two women were identified as current users of supplemental vitamin C or E. Duration of antioxidant supplement use was negatively associated with age-adjusted and weight-adjusted serum CTx, such that mean CTx levels (natural log transformed) were 0.022 units lower for each year of exposure. No significant differences were detected for adjusted serum BSAP or whole body BMD. Our results suggest that antioxidant vitamin E or C supplements may suppress bone resorption in nonsmoking postmenopausal women. Coupling of bone formation and resorption may explain the absence of an effect on bone formation markers, given evide...Continue Reading

References

Apr 1, 1995·British Medical Bulletin·P I MappD R Blake
Feb 10, 1994·The New England Journal of Medicine·J L Hopper, E Seeman
Jul 11, 1993·Biochimica Et Biophysica Acta·N SudaS Murota
Jan 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D Dreher, A F Junod
Jan 13, 1998·Journal of Epidemiology and Community Health·S G LeveilleD M Buchner
Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M C WangJ L Kelsey
Aug 12, 1998·Journal of Cellular Physiology·M J SteinbeckM J Karnovsky
Aug 14, 1998·Calcified Tissue International·S L Hall, G A Greendale
Jan 20, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H MelhusS Ljunghall
May 9, 2000·Australian and New Zealand Journal of Medicine·J A PascoM A Kotowicz
Aug 10, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P GarneroP D Delmas
Nov 23, 2000·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·M J HenryM A Kotowicz
Aug 11, 2001·Free Radical Biology & Medicine·N ModyL L Demer
Sep 11, 2001·Journal of Toxicology and Environmental Health. Part a·H S Kim, B M Lee
Oct 12, 2001·Biochemical and Biophysical Research Communications·S BasuH Melhus
Jan 11, 2003·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Cheryl OnckenLawrence G Raisz
Apr 8, 2003·The Journal of Clinical Endocrinology and Metabolism·Dario MaggioAntonio Cherubini
Sep 5, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S KaptogeJ Reeve
Nov 13, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Cathy J AitkenGeoffrey C Nicholson
Jun 11, 2005·The British Journal of Nutrition·K MundayC J Bates

❮ Previous
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Citations

Nov 21, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A ChuinI J Dionne
Apr 7, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S SahniK L Tucker
Nov 16, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J W Nieves
Apr 7, 2012·Nature Medicine·G David Roodman
Sep 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jameel IqbalMone Zaidi
Apr 2, 2014·Calcified Tissue International·Mohsen KaramatiBahram Rashidkhani
Dec 21, 2012·Cellular and Molecular Life Sciences : CMLS·Paola VendittiSergio Di Meo
Oct 5, 2011·Nutrition Reviews·Hala Ahmadieh, Asma Arabi
Jul 10, 2010·The Journal of Nutrition, Health & Aging·M Ruiz-RamosV M Mendoza-Nunez
Sep 11, 2007·The Alpha Omegan·Malcom Riley
Sep 12, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Patrick AghajanianSubburaman Mohan
Sep 21, 2013·Free Radical Biology & Medicine·Urszula T IwaniecMaret G Traber
Jan 4, 2013·International Journal of Epidemiology·Julie A PascoMark A Kotowicz
Jul 27, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K HolvikH E Meyer
Jan 1, 2014·Bone Research·Jung-Hyun KimDouglas J DiGirolamo
Oct 28, 2016·Journal of Basic and Clinical Physiology and Pharmacology·Maryam TorshabiElahe Karami
Dec 5, 2009·Aging Clinical and Experimental Research·Necat Yilmaz, Esin Eren
Sep 23, 2008·The Journal of Nutrition·Shivani SahniKatherine L Tucker
Jun 1, 2008·Acta Neuropsychiatrica·Julie A PascoMichael Berk
Aug 14, 2020·Nutrients·Olga BrzezińskaKonrad Walczak
Oct 8, 2020·Public Health Nutrition·Junichi R SakakiOck K Chun
Dec 3, 2020·Journal of Applied Oral Science : Revista FOB·Ayşe ToramanYasin Bayir

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