Antioxidants for male subfertility.

The Cochrane Database of Systematic Reviews
Roos M SmitsMarian G Showell

Abstract

The inability to have children affects 10% to 15% of couples worldwide. A male factor is estimated to account for up to half of the infertility cases with between 25% to 87% of male subfertility considered to be due to the effect of oxidative stress. Oral supplementation with antioxidants is thought to improve sperm quality by reducing oxidative damage. Antioxidants are widely available and inexpensive when compared to other fertility treatments, however most antioxidants are uncontrolled by regulation and the evidence for their effectiveness is uncertain. We compared the benefits and risks of different antioxidants used for male subfertility. This review did not examine the use of antioxidants in normospermic men. To evaluate the effectiveness and safety of supplementary oral antioxidants in subfertile men. The Cochrane Gynaecology and Fertility (CGF) Group trials register, CENTRAL, MEDLINE, Embase, PsycINFO, CINAHL, and two trials registers were searched on 1 February 2018, together with reference checking and contact with study authors and experts in the field to identify additional trials. We included randomised controlled trials (RCTs) that compared any type, dose or combination of oral antioxidant supplement with placebo,...Continue Reading

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Citations

Oct 9, 2019·European Journal of Nutrition·Elizabeth A WilliamsAllan A Pacey
Feb 23, 2020·JAMA Network Open·Feiby L NassanNiels Jørgensen
Aug 28, 2020·The Cochrane Database of Systematic Reviews·Marian G ShowellRoger J Hart
May 14, 2020·Journal of Clinical Medicine·Kinga SkorackaIwona Krela-Kaźmierczak
Oct 8, 2020·International Journal of Molecular Sciences·Rossella CannarellaAldo E Calogero
Apr 4, 2021·Biology·Elizabeth Torres-ArceAlbert Salas-Huetos
Apr 30, 2021·The Cochrane Database of Systematic Reviews·Tessy BoedtSharon Lie Fong
Jun 3, 2021·Clinical and Experimental Reproductive Medicine·Ahmed T AlahmarSulagna Dutta
Aug 8, 2021·Journal of Clinical Medicine·Paola ScaruffiPaola Anserini
Aug 10, 2021·Frontiers in Immunology·Lijun YeLianghui Diao
Aug 30, 2021·Journal of Assisted Reproduction and Genetics·Jennifer F KnudtsonAnne Z Steiner

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