Antioxidants for Pancreatic Functions in Chronic Pancreatitis: A Double-blind Randomized Placebo-controlled Pilot Study.

Journal of Clinical Gastroenterology
Namrata SinghAnoop Saraya

Abstract

Antioxidants (AO) supplementation in chronic pancreatitis (CP) has been evaluated for pain. But it is not clear whether AO in CP have an effect on pancreatic functions and other clinical outcomes. We evaluated effect of AO on endocrine function in CP. Double-blind placebo (PL)-controlled randomized pilot study on 107 patients with CP assigned to receive daily combined AO or PL for 6 months. Primary outcome was: improvement in endocrine function (Homeostasis Model Assessment-Insulin Resistance). Secondary outcome measures were: improvement in C-peptide, Qualitative Insulin Sensitivity Check Index, exocrine pancreatic function (fecal elastase), surrogate markers of fibrosis (platelet-derived growth factor BB, transforming growth factor-β1, α-smooth muscle actin), quality of life (QOL), pain, nutritional status, markers of oxidative stress (OS), AO status, and inflammation. There was an increase in levels of serum selenium (107.2±26.9 to 109.7±26.9 vs. 104.1±28.6 to 124.0±33.6 μg/L, P=0.022) and serum vitamin E [0.58 (range, 0.27-3.22) to 0.66 (range, 0.34-1.98) vs. 0.63 (range, 0.28-1.73) to 1.09 (range, 0.25-2.91) mg/dL, P=0.001] in the AO than the PL group. However, no significant differences were observed between groups in any...Continue Reading

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Citations

Oct 30, 2020·Drug Delivery·Xue JiangLongfa Kou
Mar 19, 2021·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Ayush Sharma, Ajay Kumar
Mar 19, 2021·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Srikant MohtaAnoop Saraya
Aug 16, 2021·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Asbjørn M DrewesJohn A Windsor

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