PMID: 11933117Apr 5, 2002Paper

Antioxidants from the bark of Burkea africana, an African medicinal plant

Phytotherapy Research : PTR
Elin MathisenKarl E Malterud

Abstract

The bark of the tree Burkea africana is used medicinally in large areas of sub-Saharan Africa. The constituents responsible for its putative activity are not well known. We have investigated the bark of B. africana for antioxidant and radical scavenging activity. A hydroethanol bark extract showed high activity, and most of this activity was located in semipolar fractions of the extract. From chromatographic purification and spectroscopical structure studies, we conclude that the active constituents are proanthocyanidins. Two major components appear to be fisetinidol-(4alpha- --> 8)-catechin 3-gallate and bis-fisetinidol-(4alpha- --> 6, 4alpha- --> 8)-catechin 3-gallate. The latter compound is a new natural product. Smaller amounts of monomeric flavan-3-ols (catechin, epicatechin and fisetinidol) were also found.

References

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Citations

Oct 2, 2012·BMC Complementary and Alternative Medicine·Fawzi M MahomoodallyMuhammad Iqbal Choudhary
May 30, 2013·BMC Complementary and Alternative Medicine·Werner CordierVanessa Steenkamp
Nov 26, 2015·Journal of Ethnopharmacology·Helle WangensteenBerit Smestad Paulsen
Jul 3, 2007·Phytotherapy Research : PTR·Muralikrishnan DhanasekaranBala V Manyam
Sep 24, 2005·Phytotherapy Research : PTR·Binu TharakanBala V Manyam
Jan 1, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Mary GulumianVanessa Steenkamp
Apr 8, 2020·Advances in Pharmacological and Pharmaceutical Sciences·Yakubu JibiraEric Woode
Jan 1, 2021·Oxidative Medicine and Cellular Longevity·Gundo MudauJohn Dewar
Feb 3, 2018·Journal of Natural Products·Christina E MairJudith M Rollinger
Sep 21, 2021·Natural Product Research·Romeo Toko FeunaingRodica Mihaela Dinica

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