Antioxidants have a rapid and long-lasting effect on neuritic abnormalities in APP:PS1 mice.

Neurobiology of Aging
M Garcia-AllozaBrian J Bacskai

Abstract

Senile plaques are a major pathological hallmark of Alzheimer's disease (AD). Compelling evidence suggests that senile plaques lead to structural alterations of neuronal processes and that local toxicity may be mediated by increased oxidative stress. Anti-oxidant therapy can alleviate the neuronal abnormalities in APP mice, but the time-course of this beneficial effect is unknown. We used multiphoton microscopy to assess in vivo the characteristics of antioxidant treatment on senile plaques and neurites in AD model mice (APPswe/PS1dE9). We observed that α-phenyl-N-tert-butyl nitrone (PBN), Ginkgo biloba extract (EGb 761) and Trolox had no effect on the size of existing senile plaques. However, all anti-oxidants had a straightening effect on curved neurites. This effect was detected as soon as 4 days after commencing the treatment, and was maintained after 1 month of daily treatment, with no further increase in the effect. The straightening of neurites persisted 15 days after stopping the treatment. These data indicate that neuronal plasticity is fast and still active in adult animals, and suggest that amelioration of the neuritic distortions associated with senile plaques with antioxidants is both rapid and long lasting.

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Citations

Jul 20, 2012·International Psychogeriatrics·Walter E MüllerKristina Leuner
Nov 29, 2011·Brain : a Journal of Neurology·Monica Garcia-AllozaBrian J Bacskai
Oct 19, 2010·International Journal of Alzheimer's Disease·Benoît DelatourMarc Dhenain
Aug 14, 2012·Oxidative Medicine and Cellular Longevity·Ye Feng, Xiaochuan Wang
Mar 14, 2013·Journal of Neuropathology and Experimental Neurology·Juan Jose Ramos-RodriguezMonica Garcia-Alloza
Aug 29, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Norma Serrano-GarcíaCristina Trejo-Solís
Mar 12, 2015·BioMed Research International·Iván CarreraCarmen Vigo
Sep 18, 2012·Ageing Research Reviews·Chaoyun LiHermann Schluesener
Jul 23, 2016·Molecular Neurobiology·Carmen Infante-GarciaMonica Garcia-Alloza
Jan 15, 2020·Alzheimer's Research & Therapy·Krystal SotolongoAgueda Rostagno
May 4, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Walter E MüllerHans-Jürgen Möller

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