Abstract
Senile plaques are a major pathological hallmark of Alzheimer's disease (AD). Compelling evidence suggests that senile plaques lead to structural alterations of neuronal processes and that local toxicity may be mediated by increased oxidative stress. Anti-oxidant therapy can alleviate the neuronal abnormalities in APP mice, but the time-course of this beneficial effect is unknown. We used multiphoton microscopy to assess in vivo the characteristics of antioxidant treatment on senile plaques and neurites in AD model mice (APPswe/PS1dE9). We observed that α-phenyl-N-tert-butyl nitrone (PBN), Ginkgo biloba extract (EGb 761) and Trolox had no effect on the size of existing senile plaques. However, all anti-oxidants had a straightening effect on curved neurites. This effect was detected as soon as 4 days after commencing the treatment, and was maintained after 1 month of daily treatment, with no further increase in the effect. The straightening of neurites persisted 15 days after stopping the treatment. These data indicate that neuronal plasticity is fast and still active in adult animals, and suggest that amelioration of the neuritic distortions associated with senile plaques with antioxidants is both rapid and long lasting.
References
Aug 28, 1989·Neuroscience Letters·E MasliahL A Hansen
Jul 1, 1997·Neurobiology of Aging·B T Hyman, T Gomez-Isla
Apr 30, 1998·Neurobiology of Aging·J El KhouryS C Silverstein
Jan 23, 2002·Neuropsychobiology·P L Le BarsR Hoerr
Jun 10, 2003·Nutritional Neuroscience·J A JosephD Morgan
Dec 10, 2003·Pharmacopsychiatry·S Kanowski, R Hoerr
Feb 28, 2004·Brain Research·Lourdes MassieuYves Christen
Jun 15, 2004·Neurobiology of Disease·Francesca ColciaghiMonica Di Luca
Sep 29, 2004·Neuron·Dominic M Walsh, Dennis J Selkoe
Oct 12, 2004·Nature Neuroscience·Julia TsaiWen-Biao Gan
Jun 17, 2005·Journal of Neural Transmission·K MatsumotoM Naoi
Aug 5, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tara L SpiresBradley T Hyman
Jul 4, 2006·Free Radical Biology & Medicine·Elena TamagnoMassimo Tabaton
Aug 15, 2006·European Journal of Pharmacology·Charles Ramassamy
Oct 10, 2006·Biochemical and Biophysical Research Communications·Yoichiro NishidaHidehiro Mizusawa
Oct 13, 2006·Neurobiology of Disease·Monica Garcia-AllozaMatthew P Frosch
Nov 7, 2006·Journal of Neuropathology and Experimental Neurology·Monica Garcia-AllozaBrian J Bacskai
Dec 19, 2006·The Journal of Clinical Investigation·Dora Dias-SantagataMel B Feany
Feb 20, 2007·The Journal of Biological Chemistry·Fernanda G De FeliceWilliam L Klein
May 3, 2007·Journal of Neurochemistry·M Garcia-AllozaB J Bacskai
Jul 14, 2007·Current Alzheimer Research·Charles RamassamyYves Christen
Feb 9, 2008·Free Radical Biology & Medicine·Paula I MoreiraGeorge Perry
Citations
Jul 20, 2012·International Psychogeriatrics·Walter E MüllerKristina Leuner
Nov 29, 2011·Brain : a Journal of Neurology·Monica Garcia-AllozaBrian J Bacskai
Oct 19, 2010·International Journal of Alzheimer's Disease·Benoît DelatourMarc Dhenain
Aug 14, 2012·Oxidative Medicine and Cellular Longevity·Ye Feng, Xiaochuan Wang
Mar 14, 2013·Journal of Neuropathology and Experimental Neurology·Juan Jose Ramos-RodriguezMonica Garcia-Alloza
Nov 25, 2011·International Journal of Alzheimer's Disease·Tarja MalmKatja Kanninen
Jun 20, 2015·Neurobiology of Aging·Christopher JanusDavid R Borchelt
Aug 29, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Norma Serrano-GarcíaCristina Trejo-Solís
Apr 16, 2016·Scientific Reports·Yossi MaatufHamutal Slovin
Mar 12, 2015·BioMed Research International·Iván CarreraCarmen Vigo
Sep 18, 2012·Ageing Research Reviews·Chaoyun LiHermann Schluesener
May 26, 2016·Experimental Gerontology·Wenbin WanYaming Li
Jul 22, 2016·Age·Huang HuangMing Xiao
Jul 23, 2016·Molecular Neurobiology·Carmen Infante-GarciaMonica Garcia-Alloza
Oct 16, 2015·Biological & Pharmaceutical Bulletin·Quan Feng LiuKyoung Sang Cho
Jan 15, 2020·Alzheimer's Research & Therapy·Krystal SotolongoAgueda Rostagno
May 4, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Walter E MüllerHans-Jürgen Möller
Jun 24, 2021·Scientific Reports·Elena PurisMikko Gynther
Aug 18, 2021·Journal of Pharmaceutical Sciences·Elena PurisMikko Gynther