Antioxidants inhibit ATP-sensitive potassium channels in cerebral arterioles

Stroke; a Journal of Cerebral Circulation
E P WeiJ S Beckman

Abstract

Hydrogen peroxide and peroxynitrite are capable of generating hydroxyl radical and are commonly suspected as sources of this radical in tissues. It would be useful to distinguish the source of hydroxyl radical in pathophysiological conditions and to clarify the mechanisms by which antioxidants modify vascular actions of oxidants. We investigated the effect of three antioxidants--dimethylsulfoxide (DMSO), salicylate, and L-cysteine--on the cerebral arteriolar dilation caused by topical application of hydrogen peroxide and peroxynitrite in anesthetized cats equipped with cranial windows. We also tested the effect of these antioxidants on the vasodilation caused by pinacidil and cromakalim, two known openers of ATP-sensitive potassium channels. DMSO was more effective in inhibiting dilation from hydrogen peroxide, whereas salicylate and L-cysteine were more effective in inhibiting dilation from peroxynitrite. All three antioxidants inhibited dilation in concentrations that were remarkably low (< 1 mmol/L). All three antioxidants inhibited vasodilation from two known potassium channel openers, pinacidil and cromakalim. Their effect was specific because they did not affect dilation from adenosine or nitroprusside. The findings show ...Continue Reading

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Citations

Aug 2, 2002·Pharmacology, Biochemistry, and Behavior·Mohammad TariqSaleh Al Deeb
Aug 23, 2001·Pharmacology & Therapeutics·A Bomzon, P Ljubuncic
Oct 4, 2000·British Journal of Pharmacology·P LjubuncicA Bomzon
May 3, 2002·Clinical and Experimental Pharmacology & Physiology·Yanping Liu, David D Gutterman
Aug 17, 2006·Antioxidants & Redox Signaling·Alyson A MillerChristopher G Sobey
Mar 19, 2005·Cephalalgia : an International Journal of Headache·A GozalovJ Olesen
Jul 23, 2005·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yuliya KucherenkoJohn S Gibson
Jun 15, 2016·Free Radical Biology & Medicine·Plamena R Angelova, Andrey Y Abramov
Aug 2, 2000·Arquivos de neuro-psiquiatria·R J Gagliardi
Oct 13, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Masuo OhashiDonald Heistad
Apr 1, 2006·Journal of Applied Physiology·Israel Rubinstein, Susanna G Von Essen
Jan 30, 2004·The Journal of Pharmacology and Experimental Therapeutics·Chun-Mei CaoTak-Ming Wong
Dec 7, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Marcel BassilMadhu B Anand-Srivastava
Mar 19, 2019·Frontiers in Physiology·Marie StricklandAnis Larbi

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