PMID: 9541129Apr 16, 1998Paper

Antioxidants inhibit the in vitro production of inflammatory cytokines in Crohn's disease and ulcerative colitis

European Journal of Clinical Investigation
J M ReimundP Poindron

Abstract

Modulation of cytokine secretion may be of interest in the treatment of Crohn's disease or ulcerative colitis. The effect of three antioxidants - butylated hydroxyanisol, tetrahydropapaveroline and nordihydroguaiaretic acid - on the production of tumour necrosis factor (TNF), interleukin (IL) 1, IL-6 and IL-8 (measured by enzyme-linked immunosorbent assay) by peripheral mononuclear cells and biopsies of inflamed colonic mucosa from inflammatory bowel disease patients were studied. We observed a decrease in IL-1 and IL-6 production by peripheral mononuclear cells from inflammatory bowel disease patients (approximately 50% of control). The three drugs did not decrease IL-6 and IL-8 secretion by colonic biopsies, whereas they did inhibit IL-1 and, to some degree, TNF production. The cytokine-inhibitory effect of antioxidants seems to be more pronounced in ulcerative colitis than in Crohn's disease. Our results suggest that the studied antioxidants, or related compounds, may be of interest in inflammatory bowel disease treatment.

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Citations

Oct 18, 2000·Journal of Psychosomatic Research·R Maunder
Nov 14, 2003·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·R MarionP Déchelotte
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Oct 25, 2020·Biological Trace Element Research·Mostafa Vaghari-TabariAmir Ghorbanihaghjo

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