Antioxidants of therapeutic relevance in COPD from the neotropical blueberry Anthopterus wardii.

Food Chemistry
Gema FloresEdward J Kennelly

Abstract

Four flavone C-glycosides, isoorientin (1), orientin (2), vitexin (3), and isovitexin (4), were isolated from the neotropical blueberry of Anthopterus wardii, a so-called "superfruit", using antioxidant activity-guided fractionation. A dose-response relationship of compounds 1-4 was determined for their anti-inflammatory activity against interleukin-8 (IL-8) and for the inhibition of matrix metalloproteinase-1 (MMP-1) expression, an inflammatory marker for chronic obstructive pulmonary disease. The four flavone C-glycosides exhibited inhibitory activity against IL-8 production and MMP-1 expression, with compounds 1, 3, and 4 having the most potent inhibitory activities in both assays at 100 μg/ml. The structures of compounds 1-4 were determined by spectroscopic methods. These flavone C-glycosides are reported for the first time in the Anthopterus genus.

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Citations

Apr 20, 2013·Journal of Agricultural and Food Chemistry·Shi-Biao WuShengping Zheng
Apr 4, 2013·Journal of Agricultural and Food Chemistry·Chunhui MaEdward J Kennelly
Oct 30, 2016·Fitoterapia·Miao HeBi-Wen Peng
Feb 6, 2017·Genomics & Informatics·Surya Narayan RathSukanta Kumar Pradhan
Jul 24, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Berin Karaman MayackFidele Ntie-Kang
May 4, 2021·TheScientificWorldJournal·Ibrahim Luru AbdulaiMichael Buenor Adinortey
Jul 3, 2021·International Journal of Molecular Sciences·Martina TremmelJörg Heilmann

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