Antioxidants, supplements, and Parkinson's disease

The Annals of Pharmacotherapy
Cynthia A Weber, Michael E Ernst

Abstract

To review the use of antioxidants and other supplements for the prevention and treatment of Parkinson's disease (PD). Biomedical literature was accessed through MEDLINE (1996-June 2005); key search terms included Parkinson's disease, coenzyme Q10 (CoQ10), antioxidants, supplements, and glutathione. Pertinent references cited in those articles were also evaluated for inclusion in this review. Three main antioxidants or supplements have been studied for use in the prevention or treatment of PD: tocopherol, CoQ10, and glutathione. These agents have been studied because of their potential to alter the course of 2 common theories of PD pathogenesis: free radical generation and mitochondrial complex-1 deficiency. The literature search revealed 3 large clinical studies of tocopherol (2 observational, 1 prospective randomized), 4 trials of CoQ10, and 1 study of glutathione. With the exception of the large observational studies with tocopherol and one study of CoQ10 that enrolled 80 patients, each of the other studies retrieved included fewer than 30 patients and were conducted for 3 months or less. Antioxidant supplementation, in particular tocopherol, did not appear to alter the course of PD. However, in 2 of the studies of CoQ10 and ...Continue Reading

References

Feb 1, 1989·Journal of Neurochemistry·P RiedererM B Youdim
Jan 21, 1993·The New England Journal of Medicine·UNKNOWN Parkinson Study Group
Oct 1, 1996·Progress in Neuro-psychopharmacology & Biological Psychiatry·G SechiG Rosati
Jan 1, 1997·Molecular Aspects of Medicine·E StrijksM W Horstink
Sep 12, 2001·Neurology·P R RajendranS G Reich
Oct 11, 2002·Archives of Neurology·Clifford W ShultsUNKNOWN Parkinson Study Group
Apr 1, 2003·Annals of Neurology·C Warren OlanowYves Agid
Jul 10, 2003·Lancet Neurology·C Warren Olanow
Aug 20, 2003·Archives of Neurology·Martin W I M Horstink, Baziel G van Engelen
Jan 22, 2004·JAMA : the Journal of the American Medical Association·Anthony H V Schapira, C Warren Olanow
Jul 13, 2004·Experimental Neurology·Clifford W ShultsDeborah Fontaine
Sep 1, 2004·Journal of the Neurological Sciences·Makoto SohmiyaYorihiro Yamamoto

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Citations

Jun 5, 2014·Journal of Clinical Biochemistry and Nutrition·Mototada Shichiri
Dec 19, 2012·Mitochondrion·Sofia BenfeitoFernanda Borges
Jun 12, 2012·Oxidative Medicine and Cellular Longevity·Sonia Gandhi, Andrey Y Abramov
Feb 20, 2007·Molecular Aspects of Medicine·Roberta RicciarelliCinzia Domenicotti
Feb 12, 2008·The American Journal of Medicine·Bimal H Ashar, Anastasia Rowland-Seymour
Sep 28, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sushruta KoppulaDong-Kug Choi
Feb 7, 2007·Antioxidants & Redox Signaling·Livia C Hool, Ben Corry
Jan 17, 2008·The Journal of Toxicological Sciences·Wang ZhipengLuo Xiaoxing
Dec 18, 2008·Expert Review of Proteomics·Ellen NiederbergerGerd Geisslinger
Nov 28, 2012·Journal of Neuroscience Research·Sudhakar R Subramaniam, Elizabeth M Ellis
Oct 15, 2013·British Journal of Pharmacology·I CelardoS Gandhi
Nov 2, 2015·Fluids and Barriers of the CNS·Pooja Naik, Luca Cucullo
Mar 8, 2020·Antioxidants & Redox Signaling·Carlo CervellatiGiuseppe Valacchi
Oct 8, 2017·BMC Neuroscience·Shikha PrasadLuca Cucullo
Jul 26, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carla I NietoJosé Luis Lavandera
Apr 27, 2021·European Journal of Pharmacology·Neha SharmaPuneet Utreja
May 1, 2021·International Journal of Molecular Sciences·Tapan BehlCiprian Brisc
Feb 20, 2021·CNS & Neurological Disorders Drug Targets·Olakunle J OnaolapoAdejoke Y Onaolapo

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