Antioxidants vs carotenoids. Inhibitors or promoters of experimental colorectal cancers

Archives of Surgery
T A ColacchioL Hildebrandt

Abstract

The organospecific, 1,2-dimethylhydrazine-induced murine tumor model was used to test the effects on tumor formation of the following dietary supplements: (1) ascorbic acid, 7% per weight; (2) alpha tocopherol, 1% per weight; (3) beta carotene, 1% per weight; and (4) canthazanthin, 1% per weight. Following a four-week dietary acclimation, a 16-week 1,2-dimethylhydrazine induction, and a four-week hiatus, the animals were killed, underwent autopsies, and tumor formation was recorded. The antioxidant supplements of ascorbic acid and alpha tocopherol resulted in a significant decrease in tumor formation when compared with control groups. In contrast, the beta carotene group showed no difference in tumor formation, and canthazanthin, a non-provitamin A carotenoid, resulted in an increase in tumor formation when compared with controls. In addition, the K-gel powder control diet (a carrier medium for alpha tocopherol acetate) had a significantly higher rate of tumor formation than the regular chow and placebo beadlet control diets. In sum, ascorbic acid and alpha tocopherol demonstrated a clear chemopreventive effect, whereas beta carotene had no effect, and canthazanthin appeared to function as a promoter in this organospecific tumo...Continue Reading

Citations

Feb 1, 1994·Journal of Clinical Pharmacy and Therapeutics·M TorunB Simşek
May 1, 1994·Seminars in Surgical Oncology·R L Nelson
May 1, 1990·The British Journal of Surgery·A D SpigelmanR K Phillips
May 2, 2000·Critical Reviews in Oncology/hematology·K KrishnanD E Brenner
Apr 14, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H KasaiH Mori
Dec 1, 1996·Gastroenterology Clinics of North America·K Krishnan, D E Brenner
Jan 15, 1999·Hematology/oncology Clinics of North America·K KrishnanD E Brenner

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