Antioxidative and anticarcinogenic activities of methylpheophorbide a, isolated from wheat grass (Triticum aestivum Linn.)

Natural Product Research
Priyabrata DasAshis Mukhopadhyay

Abstract

Methylphophorbide a (MPa) has been isolated from the ethanol extract of the wheat grass plant. Its antioxidative efficacy is evaluated by hydroxyl radical scavenging activities and reducing capacity which are significantly up regulated in comparison with aqueous extract of the plant. The compound shows iron-binding capacity where the Fe(2+) binds with MPa by two types of binding patterns with dissociation constants 157.17 and 27.89. It has antioxidative and cytotoxic effects on HeLa and Hep G2 cells. The cancerous cell survivability decreases with increasing concentration of MPa. These findings have provided evidence for the traditional use of the wheat grass plant in the treatment of cancers, oxidative stress and iron overloaded disorders.

References

Dec 7, 2007·Cancer Biology & Therapy·Chi Keung LauSheung Tat Fan

❮ Previous
Next ❯

Citations

Jul 1, 2017·The American Journal of Chinese Medicine·Chengyao MaYong Chen
Aug 20, 2020·Toxicology Mechanisms and Methods·Ananda Vardhan HebbaniVaradacharyulu Nallan Chakravarthula
Mar 8, 2021·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Roderick H Dashwood
Apr 1, 2020·Explore : the Journal of Science and Healing·Weijie WangYongsheng Fan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis