Antioxidative and DNA protective effects of bacillomycin D-like lipopeptides produced by b38 strain

Applied Biochemistry and Biotechnology
Olfa TabbeneFerid Limam

Abstract

In the present study, we evaluated the antioxidant and the scavenging ability of C14, C15 and C16 bacillomycin D-like lipopeptides produced by B38 strain. They all displayed strong reducing power activity, hydroxyl and superoxide anion radicals scavenging activities and inhibition of lipid peroxidation. In addition, they were found to protect plasmid DNA damage from hydroxyl radical oxidation. Data suggested that their antioxidant potency can be attributed to the hydrophobic and aromatic side-chain groups of their amino acids as well as to the aliphatic chain of their beta amino fatty acids. Note that the hydrocarbon chain length did not interfere with the antioxidant power. Overall, such bacillomycin D lipopeptides which exhibit antioxidant and radical scavenging activities may be useful for cosmetic, therapeutic or pharmaceutical purposes in order to delay or prevent oxidative deterioration of manufactured products.

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Oct 18, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Raida ZouariDhouha Ghribi-Aydi
Feb 28, 2020·Applied Microbiology and Biotechnology·Tao WuZhaoxin Lu
Aug 5, 2020·Archives of Microbiology·Lakshmi RajanRekha Devi Chakraborty
Nov 9, 2018·Archives of Microbiology·Vinaya Kizhakkepatt Kizhakkekalam, Kajal Chakraborty
Dec 12, 2016·Engineering in Life Sciences·Hanen Ben AyedMoncef Nasri

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