Antioxidative and myocardial protective effects of L-arginine in oxygen radical-induced injury of isolated perfused rat hearts

Naunyn-Schmiedeberg's Archives of Pharmacology
Astrid SuessenbacherFriedrich Brunner

Abstract

Oxygen-derived free radicals and oxidants (reactive oxygen intermediates, ROI) have been implicated in cardiovascular diseases. The protective role of nitric oxide (NO) against ROI-mediated tissue injury is not resolved. We tested the effects of exogenous NO, L- and D-arginine and a NO synthase inhibitor on electrolysis-induced cardiac injury and the generation of ROI by electrolysis. Superoxide dismutase (SOD) and catalase were used for comparison. Hearts ( n=7) from male rats (350+/-30 g) were perfused in vitro at 10 ml min(-1) g(-1), ROI generated by electrolysis of the perfusion medium (15 mA, 10 s), and cardiac function and the level of isoluminol-derived chemiluminescence in electrolysed perfusion medium documented for 15 min ( n=4). The ROI-induced maximal reduction of left ventricular developed pressure to 55+/-5% of baseline, and a 2.2+/-0.1-fold rise in coronary perfusion pressure 3 min after electrolysis, were prevented by SOD (50 U ml(-1)), catalase (100 U ml(-1)), S-nitroso- N-acetyl- D,L-penicillamine (SNAP, 100 nmol l(-1)); L-arginine (1 mmol l(-1)), N(G)-nitro- L-arginine (L-NNA, 200 micromol l(-1)) or D-arginine (1 mmol l(-1)). The effect of L-arginine was concentration dependent. In all cases, the beneficial e...Continue Reading

Citations

Jul 12, 2005·Urological Research·Viswanathan PragasamPalaninathan Varalakshmi
Apr 27, 2011·Amino Acids·Mendel Friedman, Carol E Levin
Jun 23, 2009·Journal of Cellular Biochemistry·Kylie M VenardosDavid M Kaye
Jun 22, 2010·Chemistry & Biodiversity·Mendel Friedman
Apr 7, 2006·Nitric Oxide : Biology and Chemistry·Michael AugustNikolaos Tsilimingas
Mar 31, 2005·The Annals of Thoracic Surgery·T Brett ReeceIrving L Kron

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