Antioxidative, antifungal, cytotoxic and antineurodegenerative activity of selected Trametes species from Serbia

PloS One
Aleksandar KneževićJelena Vukojević

Abstract

In a last few decades mushrooms are increasingly attracting attention as functional food and sources of biologically active compounds. Several Trametes species have been used for centuries in traditional medicine of East Asia cultures, but only T. versicolor was studied sufficiently while there are less substantial data about medicinal properties of other species. Trametes versicolor, T. hirsuta and T. gibbosa were the species tested for biological activities. Antifungal potentials of extracts were assessed for clinical strains of selected Candida and Aspergillus species. ABTS and FRAP assays were used to evaluate antioxidant capacities of studied extracts. Cytotoxic activity was determined against human cervix and lung adenocarcinoma and colon carcinoma cell lines. Antineurodegenerative activity was assessed by determining the rate of acetylcholinesterase and tyrosinase activity. The presence of metabolites in extracts of mycelia and basidiocarps of studied Trametes species was analyzed by 1H NMR spectroscopy. Studied extracts showed low antifungal potential in comparison with ketoconazole. Basidiocarp extracts were more effective ABTS+ scavengers and Fe2+ reducers than mycelium ones but less effective in comparison with L-asc...Continue Reading

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Citations

Jan 21, 2021·Microorganisms·Matthieu NicaultCyril Bontemps
Feb 11, 2020·Food Research International·Priyanka ChandraDaljit Singh Arora
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Jan 26, 2022·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Guilherme Mauro AranhaMaria de Lourdes Teixeira de Moraes Polizeli

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Methods Mentioned

BETA
ELISA
NMR

Software Mentioned

STATISTICA

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Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.