Antioxidative Effects and Mechanism Study of Bioactive Peptides from Defatted Walnut ( Juglans regia L.) Meal Hydrolysate

Journal of Agricultural and Food Chemistry
Jianyong ShengXiangliang Yang

Abstract

The peptide components of defatted walnut ( Juglans regia L.) meal hydrolysate (DWMH) remain unclear, hindering the investigation of biological mechanisms and exploitation of bioactive peptides. The present study aims to identify the peptide composition of DWMH, followed by to evaluate in vitro antioxidant effects of selected peptides and investigate mechanisms of antioxidative effect. First, more than 1 000 peptides were identified by de novo sequencing in DWMH. Subsequently, a scoring method was established to select promising bioactive peptides by structure based screening. Eight brand new peptides were selected due to their highest scores in two different batches of DWMH. All of them showed potent in vitro antioxidant effects on H2O2-injured nerve cells. Four of them even possessed significantly stronger effects than DWMH, making the selected bioactive peptides useful for further research as new bioactive entities. Two mechanisms of hydroxyl radical scavenging and ROS reduction were involved in their antioxidative effects at different degrees. The results showed peptides possessing similar capacity of hydroxyl radical scavenging or ROS reduction may have significantly different in vitro antioxidative effects. Therefore, com...Continue Reading

Citations

Mar 7, 2020·Nutrients·Julia Lorenzon Dos SantosAline Marcadenti
Mar 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiangyang LiJiangang Ma
Aug 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rosa Pérez-GregorioVictor de Freitas
Jan 25, 2020·Advanced Healthcare Materials·Zejun XuJun Wu
Jul 3, 2020·Foods·Anna JakubczykDamian Zieliński
Sep 2, 2020·Antioxidants·Mingfei PanShuo Wang
Dec 16, 2020·Protein and Peptide Letters·Tsun-Thai ChaiFai-Chu Wong
Jul 23, 2021·Food Chemistry·Chandana SosalagerePoorva Sharma

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