Antiparkinsonian and other motor effects of flupirtine alone and in combination with dopaminergic drugs

European Journal of Pharmacology
W J SchmidtG Pergande

Abstract

In this study we attempted to specify the behavioural profile of the analgesic flupirtine (1, 10 and 20 mg/kg p.o.) in the rat with respect to (i) its antiparkinsonian potential alone and as an adjunct to L-dihydroxyphenylalanine (L-DOPA) in the haloperidol-induced catalepsy (0.5 mg/kg haloperidol i.p.), (ii) locomotion and exploratory behaviour in the open field with holeboard, and (iii) possible psychomotor stimulating effects in the experimental chamber. In the two latter tests, behaviour was additionally challenged by D-amphetamine (2 mg/kg i.p.). In the catalepsy tests (horizontal bar, podium, grid) flupirtine alone was anticataleptic at doses of 10 and 20 mg/kg p.o., and the antiparkinsonian potential of a subthreshold dose of L-DOPA (50 mg/kg p.o.) was potentiated by 1 and 10 mg/kg p.o. flupirtine. On spontaneous forward locomotion in the open field with holeboard, flupirtine (1 and 10 mg/kg p.o.) had no marked effect but increased the frequency and duration of head dips, indicative for augmenting exploratory behaviour. Spontaneous rearing was reduced and D-amphetamine-induced rearing was enhanced by 1 mg/kg p.o. flupirtine. Grooming was reduced by 1 and 10 mg/kg p.o. flupirtine. In contrast, turning and grooming behavio...Continue Reading

References

Jan 1, 1992·Journal of Neural Transmission. General Section·B D KretschmerW J Schmidt
Mar 24, 1992·European Journal of Pharmacology·C Bischoff, P I Tiedtke
Oct 15, 1991·European Journal of Pharmacology·Y YoshidaT Miyagishi
Jan 1, 1990·Journal of Neural Transmission. General Section·P I TiedtkeW J Schmidt
Mar 1, 1989·Pharmacology, Biochemistry, and Behavior·W J Schmidt, M Bubser
May 1, 1983·British Journal of Anaesthesia·R A MooreJ W Lloyd
Jan 1, 1984·Current Medical Research and Opinion·R MillionJ R Whittington
Jun 1, 1995·Electroencephalography and Clinical Neurophysiology·D TimmannH C Diener
Jan 1, 1994·Journal of Neural Transmission. General Section·B D KretschmerW J Schmidt
Jan 1, 1994·Naunyn-Schmiedeberg's Archives of Pharmacology·B Zadow, W J Schmidt
Jan 1, 1996·Journal of Neural Transmission·M SchwarzF Block
Dec 1, 1995·Neurodegeneration : a Journal for Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration·S PerovicW E Müller
Jun 1, 1991·Amino Acids·W J SchmidtW Hauber

❮ Previous
Next ❯

Citations

Jun 22, 2006·Neurotoxicity Research·V Pedersen, W J Schmidt
Jun 12, 2008·Psychopharmacology·Olga FedorenkoUndine E Lang
Sep 16, 2000·European Journal of Pharmacology·J SeyfriedU Wüllner
Apr 16, 2003·Hormones and Behavior·E BujdosóG Telegdy
Mar 27, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Peter C Waldmeier
Apr 2, 2014·BioMed Research International·Rayelle Itoua MaïgaSonia Néron
Jan 5, 2008·The Journal of Physiology·Henrik H HansenJens D Mikkelsen
Jul 13, 2013·Journal of Clinical Pharmacology·Maximilian GahrCarlos Schönfeldt-Lecuona
Sep 17, 2013·Journal of Clinical Pharmacology·Maximilian GahrCarlos Schönfeldt-Lecuona
Jul 31, 2008·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Qi-liang Mao-YingYan-qing Wang
Jun 16, 2006·The Journal of Pharmacology and Experimental Therapeutics·Henrik H HansenJens D Mikkelsen
Apr 6, 2021·The European Journal of Neuroscience·Isabelle WakuAmanda R de Oliveira

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Related Papers

Progress in Neuro-psychopharmacology & Biological Psychiatry
C StoesselJ Kornhuber
Journal of Anaesthesiology, Clinical Pharmacology
S HarishTn Kumar
Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
Istvan Szelenyi
© 2021 Meta ULC. All rights reserved