PMID: 6166255Jun 1, 1981Paper

Antiperinuclear factor and keratin antibodies in rheumatoid arthritis

Annals of the Rheumatic Diseases
G D JohnsonG Russell

Abstract

Tests for antiperinuclear factor (APF) demonstrable by indirect immunofluorescence (IF) on smears of human buccal mucosal cells and for antibodies to keratin (AKA) detected on cryostat sections of rat oesophagus were performed on serum from 102 cases of rheumatoid arthritis (RA) and 117 controls. APF was detected in 92% of the cases of RA; positive tests obtained with non-RA sera were generally weaker than those given by the RA group, and the antibody in both RA and non-RA serum was predominantly IgG class. The difficulty in obtaining suitable substrate material previously reported was confirmed, and only 2 satisfactory donors were identified among 27 individuals tested. The incidence of keratin antibodies detected was found to be related to the site from which the tissue was taken; low oesophagus provided the best discrimination between RA and controls (51% and 5% positive respectively), and cardia of the stomach gave the highest incidence of staining in all groups. A laminar staining pattern was seen with most positive sera, but occasionally the keratinised layer was diffusely stained. The presence of AKA showed a marked correlation with both IgM rheumatoid factor and increased Clq binding in RA, but APF did not.

References

Jul 14, 1979·British Medical Journal·B J YoungT J Hamblin
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Mar 1, 1970·Journal of Clinical Pathology·P O'Neill, G D Johnson
Jul 1, 1964·Annals of the Rheumatic Diseases·R L NIENHUIS, E MANDEMA

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Citations

Jan 1, 1995·Rheumatology International·S Muñoz-FernándezJ Gijón-Baños
Sep 26, 1997·Journal of Dermatological Science·M ManabeH Ogawa
May 1, 1984·The Journal of Experimental Medicine·R L RubinA N Theofilopoulos
Jan 1, 1990·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·T SakuY Yagi
Jun 1, 1981·Annals of the Rheumatic Diseases·D L ScottK W Walton
Mar 1, 1992·Annals of the Rheumatic Diseases·G NesherT G Osborn
Jun 1, 1992·Annals of the Rheumatic Diseases·L PaimelaM Leirisalo-Repo
Jan 1, 1984·Rheumatology International·P YouinouY Pennec
Sep 1, 1982·Clinical Rheumatology·P MiossecM P Moineau
May 30, 2006·The International Journal of Biochemistry & Cell Biology·Bence GyörgyEdit I Buzás
Jun 12, 1999·Journal of the American Academy of Dermatology·P G Calzavara-PintonR Cattaneo
Jan 1, 1987·Scandinavian Journal of Rheumatology·H Kirstein, F K Mathiesen
Aug 1, 1995·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Y el-GamalT el-Gamasey
Jan 1, 1995·Springer Seminars in Immunopathology·J H Vaughan

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