Antiphosphatidylserine/prothrombin Antibodies in Antiphospholipid Syndrome with Intrauterine Growth Restriction and Preeclampsia

The Journal of Rheumatology
V CantiP Rovere-Querini

Abstract

Antibodies that recognize the phosphatidylserine/prothrombin complex (antiphosphatidylserine/prothrombin antibodies; aPS/PT) might reveal enhanced thrombotic risk in patients with systemic lupus erythematosus. Little is known about their association with pregnancy complications in the antiphospholipid syndrome (APS). We enrolled 55 patients with APS who were seeking pregnancy in 2 Italian hospitals. Antiphospholipid antibodies (aPL), including anticardiolipin antibodies, anti-β2-glycoprotein I antibodies, lupus-like anticoagulant, and aPS/PT antibodies were assessed, and the patients were prospectively followed for 24 months. There were 65% (36/55) of the APS patients who had aPS/PT antibodies. Forty-seven pregnancies were followed, including 33 of aPS/PT+ patients. Forty-one of the 47 patients (87%) who initiated a pregnancy eventually gave birth to a child. The pregnancy duration and the mean newborn weight at delivery were significantly lower in aPS/PT+ than in aPS/PT- patients (33.1 ± 4.7 vs 36.2 ± 3.4 wks of gestation, respectively, and 2058 ± 964 g vs 2784 ± 746 g, respectively, p < 0.05). Late pregnancy complications, including intrauterine fetal death, preterm delivery, preeclampsia, and intrauterine growth restriction ...Continue Reading

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Citations

Apr 30, 2020·American Journal of Reproductive Immunology : AJRI·Asmaa BeltagyCecilia B Chighizola
Aug 28, 2020·RMD Open·Noemie AbisrorUNKNOWN European Forum on Antiphospholipid Antibodies
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Jun 15, 2021·Current Neurology and Neuroscience Reports·Miguel Leal RatoDiana Aguiar de Sousa
Jul 20, 2021·Autoimmunity Reviews·Isabel Johanna WalterJudith Kooiman

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