Antiphospholipid antibodies and hepatitis C virus infection in Iranian thalassemia major patients

International Journal of Laboratory Hematology
S KashefM A Kashef

Abstract

Although the precise nature of Antiphospholipid antibodies is still not clearly defined, they are known to have association with thromboembolic events and have been found in hepatitis C virus (HCV) infection. Moreover, high prevalence of HCV infection and thrombotic risk is described in thalassemia. We aimed at investigating the prevalence of anticardiolipin antibodies (aCLAbs), lupus anticoagulant (LA), and their relation with HCV infection in Iranian thalassemic patients. Presence of anti-HCV antibody, serum HCV-RNA, aCLAbs, and LA activity was determined in 131 patients with thalassemia major (male/female: 63/68 aged 3-29 years) registered at thalassemia unit, Dastgheib Hospital, Shiraz, Iran. Sixty-one healthy controls were also included. Anti-HCV antibody was positive in 24 (18.3%), IgG aCLAbs in 56 (42.7%), and LA activity in 9 (6.9%) patients. 87.5% of patients positive for aCLAbs had a low titer of aCLAbs. Although none of the participants had a previous history of thrombosis, higher prevalence of aCLAbs was detected in thalassemic patients compared with controls. No significant difference in the prevalence of aCLAbs was found between HCV-infected and noninfected patients. A high prevalence of aCLAbs, the majority in lo...Continue Reading

References

Jan 1, 1992·Acta Haematologica·J MichaeliE A Rachmilewitz
Jan 1, 1991·Advances in Immunology·H P McNeilS A Krilis
Sep 12, 1998·British Journal of Haematology·P GiordanoD de Mattia
Sep 2, 2000·Journal of Autoimmunity·A E GharaviE N Harris
Dec 21, 2000·British Journal of Haematology·M D CappelliniA P Mannucci
Feb 24, 2001·Clinical Obstetrics and Gynecology·S S PierangeliE N Harris
Mar 17, 2001·Hepatology Research : the Official Journal of the Japan Society of Hepatology·S P.B. JaiswalS C. Jain
Mar 8, 2002·The New England Journal of Medicine·Jerrold S LevineJoyce Rauch
Apr 16, 2003·Annals of the Rheumatic Diseases·R A Asherson, R Cervera
Jun 22, 2005·Thrombosis and Haemostasis·Vittorio PengoSabino Iliceto
Oct 21, 2005·La Revue de médecine interne·L Darnige
Dec 13, 2005·Annals of the New York Academy of Sciences·M D CappelliniG Fiorelli
Mar 9, 2006·Hematology·Rahul NaithaniVarinder Singh
Aug 26, 2006·Nature Clinical Practice. Rheumatology·Maria Laura BertolacciniGraham R V Hughes

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Citations

Sep 30, 2008·Pakistan Journal of Biological Sciences : PJBS·Mohammad Kazemi ArababadiMahdi Mahmoodi
Oct 20, 2015·World Journal of Gastroenterology : WJG·Reza Taherkhani, Fatemeh Farshadpour

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