Antiphospholipid antibodies and the outcome of pregnancy after the first in-vitro fertilization and embryo transfer cycle

Human Reproduction
J BalaschJ A Vanrell

Abstract

Increased antiphospholipid antibody prevalence has been demonstrated by a number of recent studies in in-vitro fertilization (IVF) patients but the potential effects of antiphospholipid antibodies on the different components of the reproductive process and the consideration of whether to test IVF patients for antiphospholipid antibodies are controversial. The present study was undertaken to investigate the possible association between the presence of circulating antiphospholipid antibodies (namely the lupus anticoagulant and anticardiolipin antibodies), among a series of 21 consecutive IVF patients having a clinical spontaneous abortion after their first embryo transfer. As a control group (n=42), the nearest IVF cycle resulting in an ongoing pregnancy before and after each miscarried IVF cycle (i.e. the closest cycles in temporal relationship to the index cycle) was used. One patient (4.8%) in the study group and two women (4.8%) among controls were seropositive for antiphospholipid antibodies. These low and similar seropositivity rates found in the two groups studied lead us to conclude that antiphospholipid antibodies testing in IVF patients should be considered only in those women having repeated failures of implantation/cl...Continue Reading

Citations

Mar 10, 2001·La Revue de médecine interne·D L HuongJ C Piette
Sep 30, 1999·Current Opinion in Rheumatology·C Meng, M Lockshin
Aug 1, 2002·American Journal of Reproductive Immunology : AJRI·Zdenka Ulcová-GallováZdenek Rokyta
Aug 15, 2008·Human Reproduction Update·Scott M Nelson, Ian A Greer
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