PMID: 11897906Mar 19, 2002Paper

Antiphospholipid antibodies and infertility

Human Fertility : Journal of the British Fertility Society
May BackosLesley Regan

Abstract

Antiphospholipid antibodies (aPL) are an established cause of recurrent pregnancy loss. As defective embryonic implantation is a common link between unexplained infertility and recurrent miscarriage, interest has focused on the potential relationship between aPL and implantation failure after in vitro fertilization and embryo transfer (IVF-ET). This review critically examines the published data to determine whether women undergoing IVF-ET should be routinely screened for aPL. Although most studies have reported an increased prevalence of aPL among women undergoing IVF-ET, prospective studies examining the effect of aPL on the outcome of IVF-ET demonstrate that these antibodies do not significantly affect either the implantation or ongoing pregnancy rates. The increased prevalence of aPL among women with infertility is therefore likely to be part of a generalized autoimmune disturbance associated with infertility. Hence routine screening for aPL among women undergoing IVF-ET is not warranted and therapeutic interventions should be used only in well designed randomized controlled trials.

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Citations

Feb 22, 2012·La Revue de médecine interne·N Costedoat-ChalumeauJ Nizard
Oct 18, 2011·Autoimmunity Reviews·Claudio Galarza-MaldonadoNikolai F Soroka
Aug 12, 2008·La Revue de médecine interne·D Lê Thi HuongJ-C Piette
Jun 1, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Bee K TanStephen D Keay
Jul 11, 2003·American Journal of Reproductive Immunology : AJRI·J A McIntyre
Mar 17, 2004·Current Opinion in Obstetrics & Gynecology·Howard J A Carp

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Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.