Antiphospholipid antibodies associated with implantation failure after IVF/ET

Journal of Assisted Reproduction and Genetics
C B CoulamR G Roussev

Abstract

Our purpose was to determine the specific antiphospholipid antibodies (APAs) that should be evaluated to identify individuals at risk for implantation failure associated with reproductive autoimmune failure syndrome (RAFS). The prevalence of APAs among 312 women with implantation failure was compared with that of 100 fertile control women. To be included in the implantation failure group, each woman had to have had at least 12 embryos transferred without subsequent positive pregnancy test. Enzyme-linked immunoabsorbant assay was used to measure IgG, IgM, and IgA anticardiolipin, antiphosphatidyl ethanolamine, antiphosphatidyl inositol, antiphospatidic acid, anti-phosphatidyl glycerol, antiphosphatidyl choline, and antiphosphatidyl serine. When the values for each of the seven APAs in three isotypes were compared between women with implantation failure and the control population, all of the APAs tested had a significantly higher frequency among women with implantation failure. Positive APAs were detected in 69 (22%) of the 312 women with implantation failure compared with 5 (5%) of the 100 control women (P < 0.0001). Anticardiolipin antibodies were found in 13 (4%) of the 312 women with implantation failure and none of the contr...Continue Reading

Citations

Apr 26, 2006·American Journal of Reproductive Immunology : AJRI·Hidehiko MatsubayashiJohn A McIntyre
Jan 6, 2000·American Journal of Reproductive Immunology : AJRI·A S KaiderR G Roussev
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May 20, 2000·Annals of the New York Academy of Sciences·J HorejsíM Brandejska
Feb 24, 2001·Clinical Obstetrics and Gynecology·T F Porter
Jan 9, 2003·American Journal of Reproductive Immunology : AJRI·Carolyn B Coulam, Roumen Roussev
Dec 13, 2019·Lupus·G El HasbaniI Uthman
Dec 13, 2006·American Journal of Reproductive Immunology : AJRI·Sa-Ra LeeByung-Moon Kang
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