Antiphospholipid antibodies in the acute phase of cerebral ischaemia in young adults: a descriptive study of 139 patients

Cerebrovascular Diseases
A BlohornB Mihout

Abstract

A total of 139 young stroke patients were consecutively examined and tested for antiphospholipid antibodies (APLA) to evaluate the role of these antibodies in cerebral ischaemia before the age of 45. APLA were found in 28.8% of patients. Two factors, hypertriglyceridaemia and alcohol abuse, were significantly more frequent in patients with a positive APLA test. The demographic characteristics, other risk factors, history of prior thrombotic events and distribution of aetiopathogenic types of cerebral ischaemia were not different in patients with or without APLA. Laboratory assays for APLA were highly positive for only two patients, who both had autoimmune diseases. These results suggest that with the exception of a clinical context of antiphospholipid syndrome or other autoimmune diseases, the usefulness of this diagnostic tool in the management of cerebral ischaemia remains limited.

Citations

Oct 6, 2005·Journal of Thrombosis and Thrombolysis·Robin L Brey
Jun 20, 2014·Annals of the Rheumatic Diseases·Savino SciasciaUNKNOWN APS Action
Jan 22, 2008·Hematology/oncology Clinics of North America·Rima M Dafer, José Biller
Jun 16, 2006·Acta Neurologica Scandinavica·E PilarskaA Bakowska
Jan 13, 2004·Lupus·J Sastre-Garriga, X Montalban
Oct 23, 2010·Stroke; a Journal of Cerebral Circulation·Karen L FurieUNKNOWN American Heart Association Stroke Council, Council on Cardiovascular Nursing, Council on Clinical Cardiology, and Interdisci
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