Antiphospholipid antibodies in women with severe preeclampsia and placental insufficiency: a case-control study

Lupus
K J GibbinsD Ware Branch

Abstract

Objective Preterm delivery for preeclampsia or placental insufficiency (PREPI) is a clinical criterion for antiphospholipid syndrome (APS), but no prior prospective studies have used the international classification criteria for APS. Our objective is to determine the proportion of women with PREPI who test positive for aPL using international criteria for antiphospholipid antibody (aPL) assays. Methods We conducted a prospective, case-control study of 148 women delivered < 36 weeks because of PREPI compared to 148 controls. PREPI cases delivered < 36 weeks were compared to matched controls. Cases and controls were tested for aPL. Demographic variables were compared with chi-squared and Wilcoxon-rank-sum statistics. Rates of + aPL were compared using adjusted odds ratios (aORs) for maternal body mass index (BMI) and Caucasian race. Positive aPL (+aPL) was defined as lupus anticoagulant (LA), anticardiolipin (aCL) immunoglobulin G (IgG) (GPL) or immunoglobulin M (IgM) (MPL) ≥ 40, or anti-β2-glycoprotein I (aβ2GPI) IgG (SGU) or IgM (SMU) ≥ 40. Results Controls were more likely to be Caucasian (87% vs 70%, p = 0.006) and had lower BMIs (BMI 26 vs 33, p < 0.001). Positive aPL were found more commonly in cases than controls (11.5% vs...Continue Reading

References

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Citations

Feb 11, 2019·Scandinavian Journal of Immunology·Hui-Qing Lu, Rong Hu
Jul 18, 2020·Current Opinion in Obstetrics & Gynecology·Margreta FrishmanKaren Schreiber
Aug 12, 2020·Journal of Thrombosis and Haemostasis : JTH·Silvia G FoddaiSavino Sciascia
Dec 7, 2019·Hematology·D Ware Branch
Jun 25, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Roni ZemetMichal J Simchen
Sep 3, 2021·Immunological Medicine·Kayoko KanekoAtsuko Murashima
Jan 6, 2022·Current Rheumatology Reports·Jesse Y DabitAlí Duarte-García

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Methods Mentioned

BETA
SGA

Software Mentioned

Stata
PREPI
REDCap

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