PMID: 9430743Feb 12, 1998Paper

Antiphospholipid antibodies or not? The role of beta 2 glycoprotein 1 in autoantibody-mediated pregnancy loss

Journal of Reproductive Immunology
L W Chamley

Abstract

Antiphospholipid antibodies are a family of autoantibodies including lupus anticoagulant and anticardiolipin antibodies that appear to react with negatively charged phospholipids. These antibodies induce thrombosis and pregnancy complications including recurrent stillbirth, recurrent miscarriage, pre-eclampsia and intra-uterine growth retardation. Recent evidence indicates that antiphospholipid antibodies do not bind directly to phospholipid but rather to phospholipid-binding proteins or to a combination of phospholipid and phospholipid-binding proteins. This opens the possibility that antiphospholipid antibodies may be pathogenic by disrupting the function of phospholipid-binding proteins rather than membrane phospholipid. The antigenic role of one phospholipid-binding protein, beta 2 glycoprotein, has been studied in the greatest detail and is reviewed. Despite being highly conserved and expressed at high levels, the physiological function of beta 2 glycoprotein 1 remains unknown. However, a number of putative roles have been proposed which allow speculation as to the mechanism by which antiphospholipid antibodies may disrupt haemostasis and pregnancy.

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