Antiphospholipid autoantibody detection is important in all patients with systemic autoimmune diseases.

Journal of Autoimmunity
Adrien MarzialeYves Renaudineau

Abstract

Antiphospholipid (aPL) autoantibodies are uncommon in systemic autoimmune diseases (SADs). However, the European PRECISESADS study provides the opportunity to better characterize this rare association. The study was composed of 1818 patients with SADs including 453 with systemic lupus erythematosus (SLE), 359 with rheumatoid arthritis (RA), 385 with systemic sclerosis (SSc), 367 with Sjögren's syndrome (SjS), 94 with mixed connective tissue disease (MCTD), and 160 with undifferentiated connective tissue disease (UCTD). Assays used for aPL determination include the lupus anticoagulant (LAC) analysis using the dilute Russell's viper venom time (dRVVT) assay plus anti-cardiolipin (aCL) and anti-aβ2GPI autoantibodies of IgG and IgM isotype. Information regarding clinical and biological characteristics of SAD patients was available. Among SAD patients, the prevalence of aPL differs significantly between two groups: SLE (57.6%) and non-SLE SADs (13.7%, p < 10-4). Next, association between aPL plus thrombosis and miscarriage were observed in both SLE and non-SLE patients. Thrombosis was best predicted in SLE patients by dRVVT (OR = 6.1; IC95:3.5-10.3) and miscarriage by aCL±β2GPI IgG (OR = 2.5; IC95:1.2-5.2); while in non-SLE SADs the...Continue Reading

References

Apr 1, 1992·Annals of the Rheumatic Diseases·R A AshersonR I Fox
Sep 2, 2000·Journal of Autoimmunity·M Petri
Apr 16, 2002·Arthritis and Rheumatism·Ricard CerveraUNKNOWN Euro-Phospholipid Project Group
May 15, 2002·Annals of the Rheumatic Diseases·C VitaliUNKNOWN European Study Group on Classification Criteria for Sjögren's Syndrome
Mar 30, 2006·Current Rheumatology Reports·Ewa Olech, Joan T Merrill
Dec 7, 2006·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Raymond J EnzenauerLuis R Lopez
Jul 25, 2009·Journal of Thrombosis and Haemostasis : JTH·V PengoUNKNOWN Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the Interna
Aug 25, 2009·Rheumatology International·R GuptaA Kumar
May 11, 2011·Nature Reviews. Rheumatology·Pier Luigi MeroniFrancesco Tedesco
Jan 28, 2014·Journal of Autoimmunity·Jose A Gómez-Puerta, Ricard Cervera
Apr 3, 2014·Annals of the Rheumatic Diseases·Johanna T GustafssonElisabet Svenungsson
Aug 9, 2017·Blood Reviews·Shruti Chaturvedi, Keith R McCrae
Jan 26, 2018·Nature Reviews. Disease Primers·Karen SchreiberBeverley J Hunt
Jul 5, 2018·Frontiers in Immunology·Francesco TedescoPier Luigi Meroni
Jul 19, 2018·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Nafai SalmaRenaudineau Yves
Aug 18, 2018·Autoimmunity Reviews·Sara De CarolisAntonio Lanzone
Apr 9, 2019·Arthritis & Rheumatology·Ali Duarte-GarcíaEric L Matteson
Apr 30, 2019·Frontiers in Immunology·Paola Adele LonatiPier Luigi Meroni

❮ Previous
Next ❯

Citations

Nov 13, 2020·Clinical Reviews in Allergy & Immunology·Tingting WangXuan Zhang
Apr 11, 2021·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Hong-Tai Tzeng, I-Tsu Chyuan
May 18, 2021·Frontiers in Immunology·Sally A ClaytonAndrew R Clark

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.