Antiphospholipid syndrome nephropathy in patients with systemic lupus erythematosus and antiphospholipid antibodies: prevalence, clinical associations, and long-term outcome

Arthritis and Rheumatism
Maria G TektonidouHaralampos M Moutsopoulos

Abstract

To evaluate the prevalence, clinical associations, and outcome of antiphospholipid syndrome (APS) nephropathy in patients with systemic lupus erythematosus (SLE) and antiphospholipid antibodies (aPL) and in SLE patients without aPL. Kidney biopsy specimens obtained from 81 patients with aPL (18 of whom had APS) and 70 patients without aPL were retrospectively examined for the presence of APS nephropathy. Clinical and serologic data obtained at the time of kidney biopsy and during a mean followup of 7 years were recorded. In cases for which serial kidney biopsy specimens were available, the evolution of APS nephropathy was examined. APS nephropathy existed in 39.5% of patients with aPL, compared with only 4.3% of patients without aPL. APS nephropathy was associated with both lupus anticoagulant and anticardiolipin antibodies. Among aPL-positive SLE patients, APS nephropathy was found in two-thirds of those with APS and in one-third of those without APS. A strong association between APS nephropathy and the presence of arterial thrombosis and livedo reticularis was noted. Patients with APS nephropathy had a higher frequency of hypertension and elevated serum creatinine levels at the time of kidney biopsy but did not have a higher ...Continue Reading

References

Nov 1, 1992·Scandinavian Journal of Immunology·H P McNeilS A Krilis
Nov 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E FarrugiaK E Holley
Aug 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M D HughsonF Silva
Aug 15, 1992·Annals of Internal Medicine·M H Rosove, P M Brewer
Jun 1, 1991·Kidney International·G FramptonJ S Cameron
Aug 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G BanfiG Sacchi
Nov 1, 1990·Journal of the American Society of Nephrology : JASN·V D'AgatiG B Appel
Jan 1, 1989·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·D KleinknechtM Ramdane
Sep 1, 1987·Clinical Immunology and Immunopathology·M N ManoussakisH M Moutsopoulos
Feb 1, 1986·Human Pathology·A B MagilA Rae
Sep 1, 1983·The American Journal of Medicine·H A AustinJ E Balow
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Apr 13, 1995·The New England Journal of Medicine·M A KhamashtaG R Hughes
Jun 1, 1994·Seminars in Arthritis and Rheumatism·J C PietteB Wechsler
Apr 3, 1993·Lancet·A Hughes
Mar 24, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·F BridouxP Vanhille
Mar 12, 1999·Journal of the American Society of Nephrology : JASN·D NochyG Hill
Aug 5, 2000·QJM : Monthly Journal of the Association of Physicians·M G TektonidouH M Moutsopoulos
Dec 26, 2001·Journal of the American Society of Nephrology : JASN·Eric DaugasGary Hill

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Citations

May 14, 2009·Clinical Rheumatology·Ewa WieloszMaria Majdan
Dec 11, 2008·Clinical Reviews in Allergy & Immunology·Sonja PraprotnikBlaz Rozman
Dec 3, 2008·Clinical Reviews in Allergy & Immunology·Maria G Tektonidou
Nov 19, 2013·Best Practice & Research. Clinical Rheumatology·Frédéric A Houssiau, Bernard R Lauwerys
Aug 24, 2004·International Journal of Obstetric Anesthesia·C J Ralph
Aug 26, 2006·Nature Clinical Practice. Rheumatology·Dimitrios T BoumpasGeorge Bertsias
Nov 14, 2012·Nature Reviews. Nephrology·Ben SprangersGerald B Appel
Aug 26, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Feng YuMing-Hui Zhao
Jul 1, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Bassam AlchiDavid Jayne
Feb 8, 2006·The Pediatric Infectious Disease Journal·Ira Shah, Priya Chudgar
Aug 2, 2012·Annals of the Rheumatic Diseases·George K BertsiasUNKNOWN European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association
Apr 6, 2013·BMC Medicine·Andreas Kronbichler, Gert Mayer
May 1, 2006·Future Cardiology·Panayiotis G Vlachoyiannopoulos, Michael Samarkos
Oct 5, 2013·Archives of Disease in Childhood. Education and Practice Edition·H FreemanA V Ramanan
Dec 21, 2013·Current Rheumatology Reports·Guillermo J Pons-Estel, Ricard Cervera
Mar 20, 2014·Nature Reviews. Nephrology·Savino SciasciaDario Roccatello
Oct 6, 2006·Rheumatology International·Evandro M KlumbVicente Cervantes
Jul 24, 2014·The New England Journal of Medicine·Guillaume CanaudFabiola Terzi
Nov 6, 2012·Annual Review of Medicine·Anuja JavaJane Salmon
Nov 7, 2014·TheScientificWorldJournal·Giacomo EmmiDomenico Prisco
Jan 28, 2009·Current Rheumatology Reports·David D'Cruz
Apr 25, 2007·Critical Reviews in Clinical Laboratory Sciences·P G VlachoyiannopoulosP Tsiligros
Mar 1, 2012·Revista clínica española·G Ruiz-IrastorzaUNKNOWN Sociedad Española de Nefrología
Feb 18, 2012·La Revue de médecine interne·N Costedoat-ChalumeauJ-C Piette
Sep 9, 2010·Lancet·Guillermo Ruiz-IrastorzaMunther A Khamashta
Aug 3, 2010·Journal of Autoimmunity·Pierre Youinou
Apr 21, 2009·Medicina clínica·Guillermo Ruiz-IrastorzaM V Egurbide
Nov 26, 2008·Best Practice & Research. Clinical Rheumatology·Jean-Louis PasqualiThierry Martin
Mar 6, 2007·Seminars in Nephrology·Michael J FischerJerrold S Levine
Aug 2, 2006·Rheumatic Diseases Clinics of North America·Mary-Carmen Amigo
Sep 23, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Walter P MutterNeera K Dahl
Aug 1, 2008·Arthritis and Rheumatism·Danielle CohenIngeborg M Bajema
May 22, 2008·Clinical Transplantation·Gema Fernández-FresnedoManuel Arias
Aug 13, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K HadayaJ Villard
Apr 5, 2012·American Journal of Hematology·Thomas L Ortel
Jun 15, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G CanaudC Legendre
Feb 20, 2014·Nephrology·Thomas D BarbourSolomon J Cohney
Jun 13, 2006·Seminars in Arthritis and Rheumatism·Imad Uthman, Munther Khamashta

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