Antiplasmodial activity of acetogenins and inhibitory effect on Plasmodium falciparum adenylate translocase

Journal of Chemotherapy
M RakotomangaG Jaureguiberry

Abstract

Three Annonaceous acetogenins exhibited in vitro antimalarial activities on a chloroquine-resistant Plasmodium falciparum strain, with IC50s ranging from 5 to 10 microM. Structure-activity relationships showed that maximal antimalarial activity occurred in the presence of at least one tetrahydrofuran moiety and a synergistic action with chloroquine was observed. These acetogenins partially inhibited the P. falciparum adenylate translocase.

References

Dec 1, 1979·Antimicrobial Agents and Chemotherapy·R E DesjardinsJ D Chulay
Feb 1, 1978·The Journal of Infectious Diseases·M C Berenbaum
Aug 20, 1976·Science·W Trager, J B Jensen
Sep 1, 1992·Journal of Ethnopharmacology·P RasoanaivoA Rakoto-Ratsimamanga
Mar 1, 1990·Journal of Natural Products·J K RupprechtJ L McLaughlin

❮ Previous
Next ❯

Citations

Sep 3, 2010·Parasitology Research·Asokan BagavanDinkar Sahal
Jun 7, 2011·Parasitology Research·Chinnaperumal KamarajDinkar Sahal
Jul 9, 2011·Parasitology Research·Eugénie Aimée Madiesse KemgnePhilip J Rosenthal
Feb 28, 2015·Journal of Ethnopharmacology·Niharika SinghDinkar Sahal
May 16, 2009·Journal of Ethnopharmacology·Fabrice Fekam BoyomPhilip J Rosenthal
Nov 14, 2006·Journal of Ethnopharmacology·M L de MesquitaL S Espindola
Jan 25, 2011·Journal of Ethnopharmacology·Fabrice Fekam BoyomPhilip J Rosenthal
Feb 28, 2019·Natural Product Research·Douglas Costa GontijoAlaíde Braga de Oliveira
Sep 25, 2017·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Christian Anabí Riley-SaldañaAlma Rosa González-Esquinca

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.