Antiplasmodial activity of Indigofera spicata root extract against Plasmodium berghei infection in mice

Malaria Journal
Eshetie Melese BirruAbyot Endale Gurmu

Abstract

In addition to pharmacovigilance and pharmaco-economic concerns, resistance to anti-malarial medicines has been documented in all classes of anti-malarials and this is further worsened by resistance to common insecticides by malaria vector, which is a major threat to malaria control. As a means of facing the challenges of searching for new anti-malarial agents, the current study focused on evaluation of anti-malarial activity of root extract of Indigofera spicata. Chloroquine-sensitive rodent malaria parasite, Plasmodium berghei (ANKA strain) was used to infect the Swiss Albino mice in 4-day suppressive and curative models. The crude hydromethanolic root extract of I. spicata at 200, 400 and 600 mg/kg doses was administered to a group of five mice. Important parameters, such as level of parasitaemia, packed cell volume (PCV), survival time, and body weight were determined and the significance of the differences between mean values of the five groups was analysed by one-way ANOVA followed by post hoc Tukey's Multiple Comparison test. In both the suppressive and curative models, 400 and 600 mg/kg doses of the extract suppressed the level of parasitaemia significantly (p < 0.001) compared to the vehicle-treated groups, 34.93 and 5...Continue Reading

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Aug 7, 2016·BMC Complementary and Alternative Medicine·Eshetie Melese BirruAsegedech Tsegaw

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Citations

Aug 29, 2020·Journal of Tropical Medicine·Tekleab TekaHaile Kassahun
Sep 19, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Dawit Zewdu WondafrashBrhane Teklebrhan Assefa
Dec 10, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Prapaporn ChaniadChuchard Punsawad
Mar 2, 2018·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Serge David Dago AttemeneJoseph Alico Djaman
Feb 13, 2021·Journal of Experimental Pharmacology·Melkamu Adigo ShibeshiTezera Jemere Aragaw
Feb 1, 2020·Journal of Ethnopharmacology·Elise GeromettaAnne Gauvin-Bialecki
Jul 13, 2021·Journal of Tropical Medicine·Gebrehiwot Kiros GebremariamTsgab Gebrecherkos Girmay
Jul 6, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Gedefaw Getnet AmareZemene Demelash Kifle

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