Antiplasmodial and anti-inflammatory effects of an antimalarial remedy from the Wayana Amerindians, French Guiana: takamalaimë (Psidium acutangulum Mart. ex DC., Myrtaceae)

Journal of Ethnopharmacology
Emeline HouëlDidier Stien

Abstract

Field investigations highlighted the use of Psidium acutangulum Mart. ex DC (syn. P. persoonii McVaugh), a small tree used by the Wayana Amerindians in Twenke-Taluhwen and Antecume-Pata, French Guiana, for the treatment of malaria, and administered either orally in the form of a decoction or applied externally over the whole body. This use appears limited to the Wayana cultural group in French Guiana and has never been reported anywhere else. Our goal was to evaluate the antimalarial and anti-inflammatory activities of a P. acutangulum decoction to explain the good reputation of this remedy. Interviews with the Wayana inhabitants of Twenke-Taluhwen and Antecume-Pata were conducted within the TRAMAZ project according to the TRAMIL methodology, which is based on a quantitative and qualitative analysis of medicinal plant uses. A decoction of dried aerial parts of P. acutangulum was prepared in consistency with the Wayana recipe. In vitro antiplasmodial assays were performed on chloroquine-resistant FcB1 ([(3)H]-hypoxanthine bioassay) and 7G8 (pLDH bioassay) P. falciparum strains and on chloroquine sensitive NF54 ([(3)H]-hypoxanthine bioassay) P. falciparum strain. In vitro anti-inflammatory activity (IL-1β, IL-6, IL-8, TNFα) was e...Continue Reading

References

Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Dec 12, 1997·International Journal for Parasitology·I A ClarkL S Jacobson
Oct 8, 1999·Parasitology Today·I A Clark, W B Cowden
Apr 1, 2000·Parasite : Journal De La Société Française De Parasitologie·F Benoit-VicalF Derouin
Sep 11, 2001·Bioorganic & Medicinal Chemistry Letters·N MurakamiM Kobayashi
Jul 31, 2003·Pharmacology & Therapeutics·Ian A Clark, William B Cowden
Apr 9, 2005·Journal of Ethnopharmacology·M VigneronG Bourdy
Apr 27, 2005·Journal of Ethnopharmacology·S BertaniE Deharo
Nov 30, 2006·American Journal of Physical Anthropology·Stéphane MazièresGeorges Larrouy
Feb 24, 2007·Journal of Ethnopharmacology·P J HoughtonG Steventon
Mar 18, 2008·Travel Medicine and Infectious Disease·Ian A ClarkWilliam B Cowden
Apr 29, 2008·Journal of Ethnopharmacology·W S KokoM Iqbal Choudhary
Jun 16, 2009·Comptes rendus biologies·Jacques H C DelabieAlain Dejean
Mar 12, 2010·Journal of Clinical Microbiology·Sharon WeinHenri Vial
Aug 1, 2012·Journal of Ethnopharmacology·R Rojas-DuranE Deharo
Dec 26, 2012·Journal of Ethnopharmacology·Guillaume OdonneGeneviève Bourdy
May 3, 2014·Brazilian Journal of Biology = Revista Brasleira De Biologia·A L Marsaro JúniorR J Silva Júnior
Aug 20, 2014·European Journal of Medicinal Chemistry·Parvesh SinghVipan Kumar
Sep 4, 2014·Memórias do Instituto Oswaldo Cruz·Lise MussetEric Legrand

❮ Previous
Next ❯

Citations

Dec 15, 2015·Journal of Ethnopharmacology·Carolina Weber KffuriValdely Ferreira Kinupp
Mar 13, 2016·Phytotherapy Research : PTR·Archana SaxenaDnyaneshwar U Bawankule
Mar 19, 2021·Saudi Journal of Biological Sciences·Mohamed A DkhilMahmood A A Qasem
Apr 8, 2021·Phytotherapy Research : PTR·Betina M BeltrameAmélia T Henriques
Jun 1, 2021·Journal of Ethnopharmacology·Julimery Gonçalves Ferreira MacedoMarta Maria de Almeida Souza
Aug 12, 2021·Journal of Ethnopharmacology·Kamilla Felipe do NascimentoAnelise Samara Nazari Formagio

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.