Antiplasmodial and cytotoxic activities of the constituents of Turraea robusta and Turraea nilotica

Journal of Ethnopharmacology
Beatrice N IrunguMáté Erdélyi

Abstract

Turraea robusta and Turraea nilotica are African medicinal plants used for the treatment of a wide variety of diseases, including malaria. The genus Turraea is rich in limonoids and other triterpenoids known to possess various biological activities. From the stem bark of T. robusta six compounds, and from various parts of T. nilotica eleven compounds were isolated by the use of a combination of chromatographic techniques. The structures of the isolated compounds were elucidated using NMR and MS, whilst the relative configuration of one of the isolated compounds, toonapubesin F, was established by X-ray crystallography. The antiplasmodial activities of the crude extracts and the isolated constituents against the D6 and W2 strains of Plasmodium falciparum were determined using the semiautomated micro dilution technique that measures the ability of the extracts to inhibit the incorporation of (G-(3)H, where G is guanine) hypoxanthine into the malaria parasite. The cytotoxicity of the crude extracts and their isolated constituents was evaluated against the mammalian cell lines African monkey kidney (vero), mouse breast cancer (4T1) and human larynx carcinoma (HEp2). The extracts showed good to moderate antiplasmodial activities, wh...Continue Reading

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Citations

Apr 6, 2016·Frontiers in Plant Science·Giuseppe PuliceLuis Matías-Hernández
Sep 17, 2017·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Lazare S SidjuiMuhammad S Ali
Dec 7, 2019·Malaria Journal·Nasir Tajuddeen, Fanie R Van Heerden
Jan 7, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Boshun WanHonggeng Guan

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Methods Mentioned

BETA
column chromatography
NMR
X-ray

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ORTEP
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