Antiplasmodial and Cytotoxic Cytochalasins from an Endophytic Fungus, Nemania sp. UM10M, Isolated from a Diseased Torreya taxifolia Leaf

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Mallika KumarihamyN P Dhammika Nanayakkara

Abstract

Bioassay-guided fractionation of an EtOAc extract of the broth of the endophytic fungus Nemania sp. UM10M (Xylariaceae) isolated from a diseased Torreya taxifolia leaf afforded three known cytochalasins, 19,20-epoxycytochalasins C (1) and D (2), and 18-deoxy-19,20-epoxy-cytochalasin C (3). All three compounds showed potent in vitro antiplasmodial activity and phytotoxicity with no cytotoxicity to Vero cells. These compounds exhibited moderate to weak cytotoxicity to some of the cell lines of a panel of solid tumor (SK-MEL, KB, BT-549, and SK-OV-3) and kidney epithelial cells (LLC-PK11). Evaluation of in vivo antimalarial activity of 19,20-epoxycytochalasin C (1) in a mouse model at 100 mg/kg dose showed that this compound had weak suppressive antiplasmodial activity and was toxic to animals.

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Citations

Sep 8, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qing-Feng GuoLin Chen
Apr 3, 2019·Marine Drugs·Sara García-DavisNancy Elena Guzmán-Delgado
Oct 25, 2020·The Journal of Antibiotics·Kevin Becker, Marc Stadler
Dec 31, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mallika KumarihamyN P Dhammika Nanayakkara
Mar 7, 2021·Journal of Fungi·Bartholomew Saanu Adeleke, Olubukola Oluranti Babalola

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Datasets Mentioned

BETA
JQ761479.1
MK321315
MISS
83490

Methods Mentioned

BETA
NMR
X-ray
column chromatography
PCR
electrophoresis

Software Mentioned

Genedoc
Prism
Basic Local Alignment Search Tool ( BLAST )
BLAST
DNASTAR

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