Antiplasmodial flavanones and a stilbene from Carpha glomerata

Bioorganic & Medicinal Chemistry Letters
Namki ChoDavid G I Kingston

Abstract

Bioassay-guided fractionation of an extract of Carpha glomerata (Cyperaceae) led to the isolation of seven compounds. Compounds 1 (carphorin A), 3 (carphorin C), 4 (carphorin D), and 5 (carphabene) are new compounds, and compound 2 (8-(3″-hydroxyisoamyl)-naringenin) was isolated for the first time as a natural product. All structures were elucidated based on analyses of their HR-ESIMS and 1D and 2D NMR data. Compounds 1, 2, and 6, which have prenyl or hydroxyprenyl side chains, exhibited antiplasmodial activities with IC50 values of 5.2 ± 0.6, 3.4 ± 0.4, and 6.7 ± 0.8 µM against the drug-resistant Dd2 strain of Plasmodium falciparum. In addition the prenylated stilbene 5 also showed good activity, with IC50 5.8 ± 0.7 µM.

References

Jul 1, 1996·Journal of Natural Products·A D WrightR Desqueyroux-Faúndez
Oct 16, 2003·Journal of Agricultural and Food Chemistry·Kazuhiko NakaharaGassinee Trakoontivakorn
Nov 13, 2013·Nature Reviews. Microbiology·Erika L FlanneryElizabeth A Winzeler
May 1, 2015·Journal of Natural Products·Bo LiXin-Sheng Yao
Jun 6, 2017·Phytochemistry·Ali A El-GamalMaged S Abdel-Kader

❮ Previous
Next ❯

Citations

Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Csilla Zsuzsanna DávidAndrea Vasas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.