Antiplatelet and anticoagulant agents for primary prevention of thrombosis in individuals with antiphospholipid antibodies.

The Cochrane Database of Systematic Reviews
Malgorzata M BalaAnetta Undas

Abstract

Antiphospholipid syndrome (APS) is an autoimmune disease characterised by the presence of antiphospholipid (aPL) antibodies that have prothrombotic activity. Antiphospholipid antibodies are associated with an increased risk of pregnancy complications (recurrent miscarriage, premature birth, intrauterine growth retardation) and thrombotic events (both arterial and venous). The most common thrombotic events include brain ischaemia (stroke or transient ischaemic attack) and deep vein thrombosis. To diagnose APS, the presence of aPL antibodies in two measurements and at least one thrombotic event or pregnancy complication are required. It is unclear if people with positive aPL antibodies but without any previous thrombotic events should receive primary antithrombotic prophylaxis. To assess the effects of antiplatelet or anticoagulant agents versus placebo or no intervention or other intervention on the development of thrombosis in people with aPL antibodies who have not had a thrombotic event. We did not address obstetric outcomes in this review as these have been thoroughly addressed by other Cochrane Reviews. We searched the Cochrane Vascular Specialised Register (4 December 2017), the Cochrane Central Register of Controlled Tria...Continue Reading

References

Dec 1, 1995·The American Journal of Medicine·M Abu-ShakraV Farewell
Dec 7, 2002·Obstetrics and Gynecology·Raj Rai, Lesley Regan
Jun 19, 2004·BMJ : British Medical Journal·David AtkinsUNKNOWN GRADE Working Group
Aug 17, 2004·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Mary D StephensonMary H H Ensom
Apr 22, 2005·Journal of Thrombosis and Haemostasis : JTH·S SchulmanUNKNOWN Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on T
Apr 23, 2005·The Cochrane Database of Systematic Reviews·M EmpsonJ Scott
Sep 21, 2006·Blood·Bill GiannakopoulosSteven A Krilis
Feb 20, 2007·American Journal of Obstetrics and Gynecology·Jaime M ShamonkiRebecca N Baergen
May 29, 2007·Current Rheumatology Reports·Stephanie Hennigan, Robert Terkeltaub
Aug 25, 2007·Thrombosis Research·Raghav RajgopalStephen G Shaughnessy
Jan 1, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Spiros DendrinosEvangelos Makrakis
Feb 5, 2009·Journal of Thrombosis and Haemostasis : JTH·A TagliaferriC Pattacini
Apr 29, 2010·Current Rheumatology Reports·Robert A S Roubey
Apr 29, 2010·Current Rheumatology Reports·Pojen P Chen, Ian Giles
Dec 4, 2010·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·U M FoudaI M Fouda
Jan 22, 2011·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Usama M FoudaMahmoud M Zaki
Feb 16, 2011·British Journal of Clinical Pharmacology·Timothy D WarnerCarl Whatling
Apr 27, 2011·British Journal of Clinical Pharmacology·Yanushi Dullewe Wijeyeratne, Stan Heptinstall
May 11, 2011·Nature Reviews. Rheumatology·Pier Luigi MeroniFrancesco Tedesco
Mar 15, 2013·The New England Journal of Medicine·Bill Giannakopoulos, Steven A Krilis

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