Antiplatelet antibodies in chronic immune thrombocytopenia and their role in platelet destruction and defective platelet production

Hematology/oncology Clinics of North America
Robert McMillan

Abstract

Chronic immune thrombocytopenia (ITP) is an autoimmune disorder manifested by immune-mediated platelet destruction and suppression of platelet production. Chronic ITP characteristically has an insidious onset, usually requires therapy, and is most commonly seen in adults. The diagnosis of chronic ITP is one of exclusion and is based on the American Society of Hematology Guidelines: The patient's history, physical examination, and peripheral blood film must be consistent with the diagnosis and other causes of thrombocytopenia must be ruled out. This article reviews the role of antiplatelet autoantibody in adult chronic ITP.

References

Sep 8, 1977·The New England Journal of Medicine·D Zucker-Franklin, S Karpatkin
Jun 9, 1978·JAMA : the Journal of the American Medical Association·R McMillanR L Longmire
Aug 1, 1985·British Journal of Haematology·Y KurataR McMillan
May 1, 1974·British Journal of Haematology·I BranehögA Weinfeld
May 2, 1974·The New England Journal of Medicine·R I Handin, T P Stossel
Mar 30, 1972·The New England Journal of Medicine·R McMillanC G Craddock
Jul 1, 1970·British Journal of Haematology·L A Harker
Jan 1, 1983·Acta Haematologica·T TsubakioT Kitani
Mar 1, 1953·Annals of Internal Medicine·W J HARRINGTONR DUBACH

❮ Previous
Next ❯

Citations

Apr 10, 2013·Arthritis Research & Therapy·Stephan BlümlRonald Herbst
Nov 19, 2013·Pediatric Clinics of North America·David T Teachey, Michele P Lambert
May 30, 2013·Hematology/oncology Clinics of North America·Gaurav Kistangari, Keith R McCrae
Jul 16, 2010·British Journal of Haematology·Andreia Maria Camargos RochaDulciene Maria Magalhães Queiroz
Oct 20, 2012·European Journal of Haematology·Fan-Chen KuWen-Li Hwang
Aug 26, 2015·British Journal of Haematology·Ellinor I B PeerschkeJames Bussel
Jul 18, 2015·Biomarker Research·Lingjia YuXuebin Ji
May 17, 2013·Seminars in Hematology·Alan H LazarusDouglas B Cines
Jun 11, 2016·Critical Reviews in Clinical Laboratory Sciences·Xiaohong Ruby XuHeyu Ni
Jun 28, 2017·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Hadi RezaeeyanNajmaldin Saki
Oct 3, 2017·Immunotherapy·Adrian NewlandJames B Bussel
Dec 9, 2014·Laboratory Investigation; a Journal of Technical Methods and Pathology·Shuang YuDaoxin Ma
Aug 27, 2010·Current Opinion in Hematology·John W SempleJohn Freedman
Sep 25, 2010·Blood·Theodore E Warkentin, Julia A M Anderson
Dec 11, 2019·American Journal of Hematology·Adrian C NewlandDavid J Kuter
Oct 18, 2016·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Deependra K YadavAloukick K Singh
Aug 7, 2012·Journal of Thrombosis and Haemostasis : JTH·S Lakshmanan, A Cuker
Apr 24, 2018·Journal of Veterinary Internal Medicine·Kelly M MakielskiDana N LeVine
Mar 17, 2021·Expert Review of Clinical Pharmacology·Rajeev SandalAhmad Daniyal Siddiqui
Jun 15, 2019·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Minodora OnisâiHoria Bumbea

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.