Antiplatelet antibody [7E3 F(ab')2] prevents rethrombosis after recombinant tissue-type plasminogen activator-induced coronary artery thrombolysis in a canine model

Circulation
J K MickelsonB R Lucchesi

Abstract

Coronary artery rethrombosis can complicate initially effective thrombolytic therapy. Platelets interacting with injured vascular endothelium in a region along the coronary artery with reduced luminal cross-sectional area contribute to rethrombosis. The purpose of this study was to investigate the potential of the F(ab')2 fragment of the murine monoclonal antibody 7E3 [7E3 F(ab')2] to prevent rethrombosis after intracoronary clot lysis with recombinant tissue-type plasminogen activator (rt-PA) in an experimental model. The 7E3 F(ab')2 binds to the platelet glycoprotein IIb/IIIa complex (GPIIb/IIIa), thereby preventing platelet-fibrinogen interaction and intravascular thrombus formation. Experimental coronary artery thrombosis was produced in the anesthetized dog by application of direct anodal current to the intimal surface of the left circumflex coronary artery in the region of an external stenosis. Lysis of the established intracoronary thrombus was achieved with the intravenous administration of rt-PA (25 mg) after which the animals were randomized into two groups. Group 1 (n = 10) served as the control, receiving the saline diluent, and group 2 (n = 9) received 7E3 F(ab')2, given as a single intravenous injection (0.8 mg/kg...Continue Reading

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Citations

Dec 29, 2000·Journal of the American College of Cardiology·J G KingmaP Bogaty
Jan 22, 2002·Journal of the American College of Surgeons·Richard Shlansky-Goldberg
Mar 27, 2003·Journal of Cardiovascular Pharmacology·Martin MoserJohannes Ruef
Jun 27, 2003·Journal of Cardiovascular Pharmacology·James K HennanBenedict R Lucchesi
Jun 18, 2002·Journal of Interventional Cardiology·Deepak P VivekananthanDavid J Moliterno
Jan 1, 1991·The Journal of Clinical Investigation·E Ruoslahti
Nov 1, 1991·The Journal of Clinical Investigation·D J FitzgeraldG A FitzGerald
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Jun 1, 1994·Stroke; a Journal of Cerebral Circulation·W E RoteB R Lucchesi

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